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Section 1 - Chemical Product and Company Identification |
MSDS Name: Ethynylestradiol 3-methyl ether, 97%
Catalog Numbers:
AC227190000, AC227191000, AC227195000
Synonyms:
3-Methoxyethynylestradiol; 3-Methoxy-17-alpha-ethynylestradiol;
17-Ethynyloestradiol 3-methyl ether;
Company Identification:
Acros Organics N.V.
One Reagent Lane
Fair Lawn, NJ 07410
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300
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Section 2 - Composition, Information on Ingredients
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| CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
| 72-33-3 |
Ethynylestradiol 3-methyl ether |
97% | 200-777-8 |
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Section 3 - Hazards Identification
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EMERGENCY OVERVIEW
Appearance: white powder.
Caution! May cause mechanical eye irritation.
Cancer suspect agent. This product contains Ethynylestradiol
3-methyl ether, a chemical known to the state of California to cause
developmental effects.
Target Organs: Liver, reproductive system.
Potential Health Effects
Eye:
May cause mechanical irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause nausea and vomiting.
Inhalation:
May cause respiratory tract irritation.
Chronic:
May cause cancer according to animal studies. Adverse reproductive
effects have been reported in humans. Cancer suspect agent.
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Section 4 - First Aid Measures
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Eyes:
Flush eyes with plenty of water for at least 15 minutes, occasionally
lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15
minutes while removing contaminated clothing and shoes.
Ingestion:
Call a poison control center. If swallowed, do not induce vomiting
unless directed to do so by medical personnel. Never give anything by
mouth to an unconscious person. Get medical aid.
Inhalation:
Remove from exposure and move to fresh air immediately. If not
breathing, give artificial respiration. If breathing is difficult,
give oxygen. Get medical aid. Do NOT use mouth-to-mouth
resuscitation.
Notes to Physician:
Treat symptomatically and supportively.
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Section 5 - Fire Fighting Measures
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General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.
Flash Point: Not applicable.
Autoignition Temperature: Not applicable.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating:
(estimated) Health: 1; Flammability: 0; Instability: 0
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Section 6 - Accidental Release Measures
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General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal
container. Avoid generating dusty conditions. Provide ventilation.
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Section 7 - Handling and Storage
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Handling:
Wash thoroughly after handling. Use with adequate ventilation.
Minimize dust generation and accumulation. Avoid contact with eyes,
skin, and clothing. Avoid ingestion and inhalation. Use only in a
chemical fume hood.
Storage:
Do not store in direct sunlight. Store in a tightly closed
container. Hormones and antibiotics room. Store in a cool, dry area
away from incompatible substances.
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Section 8 - Exposure Controls, Personal Protection
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Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate
ventilation to keep airborne concentrations low.
Exposure Limits
| Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
| Ethynylestradiol 3-methyl ether
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none listed
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none listed
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none listed
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OSHA Vacated PELs:
Ethynylestradiol 3-methyl ether:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to minimize
contact with skin.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant respirator use.
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Section 9 - Physical and Chemical Properties
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Physical State: Powder
Appearance: white
Odor: none reported
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:153 - 155 deg C
Decomposition Temperature:Not available.
Solubility: slightly soluble in methanol
Specific Gravity/Density:Not available.
Molecular Formula:C21H26O2
Molecular Weight:310.1808
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Section 10 - Stability and Reactivity
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Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, light.
Incompatibilities with Other Materials:
Strong oxidizing agents, acid anhydrides.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.
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Section 11 - Toxicological Information
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RTECS#:
CAS# 72-33-3:
RC8960000
LD50/LC50:
CAS# 72-33-3:
Oral, mouse: LD50 =
>10 gm/kg;
Oral, rat: LD50 = >10
gm/kg;
.
Carcinogenicity:
CAS# 72-33-3:
- ACGIH:
Not listed.
- California:
carcinogen, initial date 4/1/88
- NTP:
Not listed.
- IARC:
Group 1 carcinogen
Epidemiology:
IARC Group 2A: Suspected human carcinogenic substance.
Teratogenicity:
Teratogenic effects have occurred in humans.
Reproductive Effects:
Adverse reproductive effects have occurred in humans.
Mutagenicity:
Mutagenic effects have occurred in humans.
Neurotoxicity:
No information found
Other Studies:
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Section 12 - Ecological Information
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No information available.
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Section 13 - Disposal Considerations
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Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
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Section 14 - Transport Information
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US DOT |
Canada TDG |
| Shipping Name: |
Not regulated as a hazardous material |
No information available. |
| Hazard Class: |
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| UN Number: |
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| Packing Group: |
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Section 15 - Regulatory Information
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US FEDERAL
TSCA
CAS# 72-33-3 is not listed on the TSCA inventory.
It is for research and development use only.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
Section 313
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product
are listed as Hazardous Substances under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product
are considered highly hazardous by OSHA.
STATE
CAS# 72-33-3 can be found on the
following state right to know lists: California, New Jersey,
Pennsylvania, Minnesota, Massachusetts.
California Prop 65
The following statement(s) is(are) made in order to comply with
the California Safe Drinking Water Act:
WARNING: This product contains Ethynylestradiol 3-methyl ethe, a
chemical known to the state of California to cause cancer.
WARNING: This product contains Ethynylestradiol 3-methyl ethe, a
chemical known to the state of California to cause developmental
reproductive toxicity.
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
XN
Risk Phrases:
R 33 Danger of cumulative effects.
Safety Phrases:
S 45 In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
WGK (Water Danger/Protection)
CAS# 72-33-3: 2
Canada - DSL/NDSL
CAS# 72-33-3 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of D2A.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
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Section 16 - Additional Information
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MSDS Creation Date: 9/02/1997
Revision #7 Date: 3/15/2007
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.
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