*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : KH8008500
CHEMICAL NAME : Ethane, 2-chloro-1,1,1-trifluoro-
CAS REGISTRY NUMBER : 75-88-7
BEILSTEIN REFERENCE NO. : 1733200
REFERENCE : 4-01-00-00128 (Beilstein Handbook Reference)
LAST UPDATED : 199710
DATA ITEMS CITED : 10
MOLECULAR FORMULA : C2-H2-Cl-F3
MOLECULAR WEIGHT : 118.49
COMPOUND DESCRIPTOR : Tumorigen
SYNONYMS/TRADE NAMES :
* CFC 133a
* 1-Chloro-2,2,2-trifluoroethane
* 2-Chloro-1,1,1-trifluoroethane
* FC 133a
* Freon 133a
* Genetron 133a
* R 133a
* 1,1,1-Trifluoro-2-chloroethane
* 2,2,2-Trifluorochloroethane
* 1,1,1-Trifluoroethyl chloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 15 pph/1H
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
BJANAD British Journal of Anesthesia. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.1- 1923- Volume(issue)/page/year:
37,716,1965
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 33000 ppm/5H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - structural or functional change in trachea
or bronchi
Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0530594
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 10 pph/1H/25D-I
TOXIC EFFECTS :
Behavioral - general anesthetic
Liver - fatty liver degeneration
Kidney, Ureter, Bladder - interstitial nephritis
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0528422
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 78 gm/kg/1Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Reproductive - Tumorigenic effects - testicular tumors
Reproductive - Tumorigenic effects - uterine tumors
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
72,15,1984
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 41,253,1986
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 41,253,1986
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***
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