Arsine
Product: Arsine P-4565-F Date: August 2000
Praxair Material Safety Data Sheet
1. Chemical Product and Company Identification
Product Name: Arsine (MSDS No. P-4565-F) Trade Name: Arsine
Chemical Name: Arsine Synonyms: Arsenic hydride, arsenic
trihydride, arseniuretted hydrogen, arsenous
hydride, hydrogen arsenide
Chemical Family: Inorganic Hydride
Formula: AsH3
1-800-645-4633* Company Name: Praxair, Inc.
Telephone: Emergencies:
1-800-424-9300* 39 Old Ridgebury Road
CHEMTREC:
1-800-PRAXAIR Danbury, CT 06810-5113
Routine:
* Call emergency numbers 24 hours a day only for spills, leaks, fire, exposure, or accidents involving this
product. For routine information, contact your supplier, Praxair sales representative, or call
1-800-PRAXAIR (1-800-772-9247).
2. Composition/Information on Ingredients
For custom mixtures of this product, request an MSDS for each component.
See section 16 for important information about mixtures.
INGREDIENT CAS NUMBER CONCENTRATION OSHA PEL ACGIH TLV-TWA
Arsine 7784-42-1 >99%* 0.05 ppm 0.05 ppm
* The symbol > means ??greater than??; the symbol <, ??less than.??
3. Hazards Identification
EMERGENCY OVERVIEW
DANGER! Toxic, flammable liquid and gas under pressure.
May be fatal if inhaled.
Causes severe red blood cell, lung, liver,
kidney, nervous system, and heart damage.
Liquid may cause frostbite.
Symptoms may be delayed.
May form explosive mixtures with air.
Suspect cancer hazard.
Self-contained breathing apparatus must be worn by rescue workers.
Odor: Garlic-like
THRESHOLD LIMIT VALUE: TLV-TWA, 0.05 ppm, ACGIH (1999). TLV-TWAs should be used as
a guide in the control of health hazards and not as fine lines between safe and dangerous concentrations.
Copyright ? 1979, 1985, 1989, 1992, 1997, 2000, Praxair Technology, Inc.
All rights reserved.
Revised
Product: Arsine P-4565-F Date: August 2000
EFFECTS OF A SINGLE (ACUTE) OVEREXPOSURE:
INHALATION?CExtremely toxic. May be fatal if inhaled. Arsine rapidly destroys red blood cells
(intravascular hemolysis). It also produces hemoglobin in the urine (hemoglobinuria) with
accompanying dark urine. The breath may smell of garlic. Weakness, shivering, decreased blood
pressure, dizziness, headache, nausea, vomiting, and diarrhea may occur. The victim may complain of
thirst, have pain in the abdomen and flanks, and may collapse. Acute exposure to high concentrations
can make breathing difficult and cause pulmonary edema.
The interval between exposure and onset of symptoms depends on gas concentration and duration of
exposure. Symptoms can be delayed up to 48 hours. Concentrations in excess of 50 ppm are rapidly
fatal.
SKIN CONTACT?CNo expected damage to skin from vapor. Liquid may cause frostbite.
SWALLOWING?CAn unlikely route of exposure, but frostbite of the lips and mouth may result from
contact with the liquid. This product is a gas at normal temperature and pressure.
EYE CONTACT?CNo expected harm to eye tissue from vapor. Liquid may cause frostbite.
EFFECTS OF REPEATED (CHRONIC) OVEREXPOSURE: Repeated exposure can produce
anemia, cardiovascular disease, and peripheral neuropathy (numbness, tingling, and weakness in the
hands and feet). When inhaled, arsine produces inorganic arsenic; repeated exposure to which may darken
and thicken the skin.
OTHER EFFECTS OF OVEREXPOSURE: Delayed effects include hemolytic anemia, jaundice and
bronzing of the skin, pulmonary edema, and peripheral neuropathy. Severe overexposure can damage
kidneys, liver, and heart. Kidney failure with oliguria or anuria can lead to uremia and death.
MEDICAL CONDITIONS AGGRAVATED BY OVEREXPOSURE: Individuals with anemia or
preexisting kidney, heart, liver, or nervous system disease may be at increased risk.
SIGNIFICANT LABORATORY DATA WITH POSSIBLE RELEVANCE TO HUMAN HEALTH
HAZARD EVALUATION: The International Agency for Research on Cancer (IARC) has reported that
there is sufficient evidence that inorganic arsenic compounds are human skin and lung carcinogens.
CARCINOGENICITY: Inorganic arsenic is listed by NTP (human carcinogen), OSHA (cancer hazard),
and IARC (human carcinogen, group 1).
4. First Aid Measures
INHALATION: Immediately remove to fresh air. If not breathing, give artificial respiration. If
breathing is difficult, qualified personnel may give oxygen. Get immediate medical attention, even if no
symptoms are present.
SKIN CONTACT: If exposed to liquid, avoid breathing vapor. Flush with water and warm frostbite
area with warm water not to exceed 105??F (41??C). In case of massive exposure, remove clothing while
showering with warm water. Get immediate medical attention.
SWALLOWING: An unlikely route of exposure. This product is a gas at normal temperature and
pressure.
EYE CONTACT: In case of splash contamination, immediately flush eyes thoroughly with warm water
for at least 15 minutes. Hold the eyelids open and away from the eyeballs to ensure that all surfaces are
flushed thoroughly. Seek the advice of a physician, preferably an ophthalmologist, immediately.
NOTES TO PHYSICIAN: Arsine is the most toxic form of arsenic, capable of producing rapid, massive
intravascular hemolysis. Serious arsine poisoning produce symptoms within 30 to 60 minutes; however,
symptoms can be delayed for up to 48 hours. Laboratory findings include severe hemolytic anemia,
Product: Arsine P-4565-F Date: August 2000
hemoglobinuria and hemoglobinemia. Acute renal failure may be an early complication. Hypotension is
occasionally seen; T-wave elevations often observed.
BAL (Dimercaprol) treatment will not protect against hemolysis but may prevent long-term effects from
arsine (arsenic) poisoning. If major hemolysis has occurred, exchange transfusions may be performed to
remove plasma hemoglobin red blood cell debris and arsine-hemoglobin complexes, in conjunction with
hemodialysis to preserve renal function. Hemodialysis may also assist in decreasing arsenic levels.
Contact the Poison Control Center in your area for additional information on patient management and
follow-up.
5. Fire Fighting Measures
FLASH POINT (test method): Flammable gas
AUTOIGNITION TEMPERATURE: Currently unknown
FLAMMABLE LIMITS IN AIR, % by volume: LOWER: 4.5% UPPER: 78%
EXTINGUISHING MEDIA: CO2, dry chemicals, water spray, or fog.
SPECIAL FIRE FIGHTING PROCEDURES: DANGER! Toxic, flammable liquid and gas under
pressure (see section 3). Evacuate all personnel from danger area. Do not approach area without self-
contained breathing apparatus and protective clothing. Immediately cool cylinders with water spray from
maximum distance, taking care not to extinguish flames. Solid streams of water may be ineffective.
Remove ignition sources if without risk. If flames are accidentally extinguished, explosive reignition may
occur. Reduce toxic vapors with water spray or fog. Stop flow of gas if without risk, while continuing
cooling water spray. Remove all containers from area of fire if without risk. Allow fire to burn out. On-
site fire brigades must comply with OSHA 29 CFR 1910.156.
UNUSUAL FIRE AND EXPLOSION HAZARDS: Forms explosive mixtures with air and oxidizing
agents. Heat of fire can build pressure in cylinder and cause it to rupture. To provide maximum
containment up to cylinder burst pressure, arsine cylinders are not equipped with a pressure relief device.
No part of cylinder should be subjected to a temperature higher than 125??F (52??C). If leaking or spilled
arsine catches fire, do not extinguish flames. Flammable and toxic vapors may spread from leak and could
explode if reignited by sparks or flames. Explosive atmospheres may linger. Before entering area,
especially confined areas, check with an appropriate device. To protect persons from cylinder fragments
and toxic fumes should a rupture occur, evacuate the area if the fire cannot be brought under immediate
control.
HAZARDOUS COMBUSTION PRODUCTS: None known.
6. Accidental Release Measures
STEPS TO BE TAKEN IF MATERIAL IS RELEASED OR SPILLED: DANGER! Toxic,
flammable liquid and gas under pressure (see section 3). Immediately evacuate all personnel from
danger area. Do not approach area without self-contained breathing apparatus and protective clothing.
Gas forms explosive mixtures with air (see section 5). Toxic, flammable vapors may spread from spill.
Before entering area, especially a confined area, check atmosphere with an appropriate device. Remove
all sources of ignition if without risk. Reduce vapors with fog or fine water spray. Shut off flow if without
risk. Ventilate area of leak or move cylinder to well-ventilated area. Prevent runoff from contaminating
surrounding environment.
Product: Arsine P-4565-F Date: August 2000
EMERGENCY DISPOSAL: Arsine can be slowly introduced into a gas disposal system containing
adequate quantities of sodium hypochlorite, calcium hypochlorite, potassium permanganate, bromine
water, or sodium hypobromite solution.
7. Handling and Storage
PRECAUTIONS TO BE TAKEN IN STORAGE: Store and use with adequate ventilation. Separate
arsine cylinders from oxygen and other oxidizers by at least 20 ft (6.1 m) or use a barricade of
noncombustible material. This barricade should be at least 5 ft (1.53 m) high and have a fire resistance
rating of at least ? hour. Firmly secure cylinders upright to keep them from falling or being knocked
over. Screw valve protection cap firmly in place by hand. Store only where temperature will not exceed
125??F (52??C). Store full and empty cylinders separately. Use a first-in, first-out inventory system to
prevent storing full cylinders for long periods. Post "No Smoking or Open Flames" signs in storage and
use areas. There must be no sources of ignition. All electrical equipment in storage areas must be
explosion-proof. Storage areas must meet national electric codes for Class 1 hazardous areas.
PRECAUTIONS TO BE TAKEN IN HANDLING: Protect cylinders from damage. Use a suitable
hand truck to move cylinders; do not drag, roll, slide, or drop. Electrical equipment must be non-sparking
or explosion-proof. Never attempt to lift a cylinder by its cap; the cap is intended solely to protect the
valve. Never insert an object (e.g., wrench, screwdriver, pry bar) into cap openings; doing so may damage
the valve and cause a leak. Use an adjustable strap wrench to remove over-tight or rusted caps. Open
valve slowly. If valve is hard to open, discontinue use and contact your supplier. For other precautions in
using arsine, see section 16.
8. Exposure Controls/Personal Protection
VENTILATION/ENGINEERING CONTROLS:
LOCAL EXHAUST?CUse explosion-proof local exhaust ventilation with sufficient air flow to keep
the arsine concentration below the TLV in the worker's breathing zone.
MECHANICAL (general)?CNot recommended as a primary ventilation system to control worker's
exposure.
SPECIAL?CA canopy type of forced-air fume hood equipped with an explosion-proof device may be
more desirable for certain applications.
OTHER?CNot applicable.
RESPIRATORY PROTECTION: Use air-supplied respirators for concentrations up to 10 times the
applicable permissible exposure limit. For higher concentrations, a full-face, self-contained breathing
apparatus is required. Respiratory protection must conform to OSHA rules as specified in 29 CF
1910.134.
SKIN PROTECTION: Neoprene.
EYE PROTECTION: Wear safety glasses when handling cylinders. Select per OSHA 29 CF
1910.133.
OTHER PROTECTIVE EQUIPMENT: Metatarsal shoes for cylinder handling and protective
clothing where needed. Select per OSHA 29 CFR 1910.132 and 1910.133. Regardless of protective
equipment, never touch live electrical parts.
Product: Arsine P-4565-F Date: August 2000
9. Physical and Chemical Properties
MOLECULAR WEIGHT: 77.95
SPECIFIC GRAVITY (Air = 1) at 70??F (21.1??C) and 1 atm: 2.69
0.2025 lb/ft3 (3.24 kg/m3)
GAS DENSITY at 68??F (20??C) and 1 atm:
VAPOR PRESSURE at 70??F (21.1??C): 219.7 psia (1514.7 kPa, abs)
SOLUBILITY IN WATER: Slight
PERCENT VOLATILES BY VOLUME: 100
EVAPORATION RATE (Butyl Acetate = 1): High
BOILING POINT at 1 atm: -80.5??F (-62.5??C)
FREEZING POINT at 1 atm: -178.4??F (-116.7??C )
APPEARANCE, ODOR, AND STATE: Colorless gas at normal temperature and pressure; garlic-
like odor.
10. Stability and Reactivity
STABILITY: Unstable Stable
INCOMPATIBILITY (materials to avoid): Nitric acid, oxidizing agents, aluminum, halogens,
potassium, and ammonia.
HAZARDOUS DECOMPOSITION PRODUCTS: Arsenic, arsenic oxides, hydrogen.
HAZARDOUS POLYMERIZATION: May Occur Will Not Occur
CONDITIONS TO AVOID: Exposure to light or heat in the presence of moisture. Decomposition
occurs at temperatures on the order of 446-464??F (230-240??C).
11. Toxicological Information
See section 3.
12. Ecological Information
No information available on ecological effects. Arsine does not contain any Class I or Class II ozone-
depleting chemicals. Arsine is not listed as a marine pollutant by DOT.
13. Disposal Considerations
WASTE DISPOSAL METHOD: Do not attempt to dispose of residual or unused quantities. Return
cylinder to supplier. For emergency disposal, see section 6.
Product: Arsine P-4565-F Date: August 2000
14. Transport Information
DOT/IMO SHIPPING NAME: Arsine
HAZARD IDENTIFICATION PRODUCT
2.3 UN 2188 RQ: None
CLASS: NUMBER:
POISON GAS, FLAMMABLE GAS*
SHIPPING LABEL(s):
POISON GAS, FLAMMABLE GAS*
PLACARD (when required):
*The words In the POISON GAS diamond are INHALATION HAZARD.
SPECIAL SHIPPING INFORMATION: Cylinders should be transported in a secure position, in a
well-ventilated vehicle. Cylinders transported in an enclosed, nonventilated compartment of a vehicle can
present serious safety hazards.
Additional Marking: INHALATION HAZAR
Shipment of compressed gas cylinders that have been filled without the owner's consent is a violation of
federal law [49 CFR 173.301(b)].
15. Regulatory Information
The following selected regulatory requirements may apply to this product. Not all such requirements are
identified. Users of this product are solely responsible for compliance with all applicable federal, state,
and local regulations.
U.S. FEDERAL REGULATIONS:
EPA (ENVIRONMENTAL PROTECTION AGENCY)
CERCLA: COMPREHENSIVE ENVIRONMENTAL RESPONSE, COMPENSATION, AN
LIABILITY ACT OF 1980 (40 CFR Parts 117 and 302):
Reportable Quantity (RQ): 1 lb (0.454 kg)
SARA: SUPERFUND AMENDMENT AND REAUTHORIZATION ACT:
SECTIONS 302/304: Require emergency planning based on Threshold Planning Quantity
(TPQ) and release reporting based on Reportable Quantities (RQ) of extremely hazardous
substances (40 CFR Part 355):
Threshold Planning Quantity (TPQ): 100 lb (45.4 kg)
Extremely Hazardous Substances (40 CFR 355): 100 lb (45.4 kg)
SECTIONS 311/312: Require submission of MSDSs and reporting of chemical inventories
with identification of EPA hazard categories. The hazard categories for this product are as
follows:
IMMEDIATE: Yes PRESSURE: Yes
DELAYED: Yes REACTIVITY: Yes
FIRE: Yes
SECTION 313: Requires submission of annual reports of release of toxic chemicals that
appear in 40 CFR Part 372.
Arsine is subject to the reporting requirements of this section.
Product: Arsine P-4565-F Date: August 2000
40 CFR 68: RISK MANAGEMENT PROGRAM FOR CHEMICAL ACCIDENTAL
RELEASE PREVENTION: Requires development and implementation of risk management
programs at facilities that manufacture, use, store, or otherwise handle regulated substances in
quantities that exceed specified thresholds.
Arsine is listed as a regulated substance in quantities of 1,000 lb (454 kg) or greater.
TSCA: TOXIC SUBSTANCES CONTROL ACT: Arsine is listed on the TSCA inventory.
OSHA: OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION:
29 CFR 1910.119: PROCESS SAFETY MANAGEMENT OF HIGHLY HAZARDOUS
CHEMICALS: Requires facilities to develop a process safety management program based on
Threshold Quantities (TQ) of highly hazardous chemicals.
Arsine is listed in Appendix A as a highly hazardous chemical in quantities of 100 lb (45.4
kg) or greater.
STATE REGULATIONS:
CALIFORNIA: Arsine (as inorganic arsenic)is listed by California under the SAFE DRINKING
WATER AND TOXIC ENFORCEMENT ACT OF 1986 (Proposition 65).
WARNING: Inorganic arsenic compounds are chemicals known to the State of California to
cause cancer.
(California Health and Safety Code ??25249.5 et seq.)
PENNSYLVANIA: This product is subject to the PENNSYLVANIA WORKER AN
COMMUNITY RIGHT-TO-KNOW ACT (35 P.S. Sections 7301-7320).
16. Other Information
Be sure to read and understand all labels and instructions supplied with all containers of this product.
OTHER HAZARDOUS CONDITIONS OF HANDLING, STORAGE, AND USE: Toxic,
flammable liquid and gas under pressure. May be fatal if inhaled. Do not breathe gas. Do not get vapors
or liquid in eyes, on skin, or on clothing. (See section 3.) Have safety showers and eyewash fountains
immediately available. Use piping and equipment adequately designed to withstand pressures to be
encountered. May form explosive mixtures with air. Keep away from heat, sparks, or open flame.
Ground all equipment. Use only spark-proof tools and explosion-proof equipment. Store and use with
adequate ventilation at all times. Use only in a closed system. Close valve after each use; keep closed
even when empty. Keep away from oxidizing agents and from other flammables. Never work on a
pressurized system. If there is a leak, close the cylinder valve. Blow down the system in an
environmentally safe manner in compliance with all federal, state, and local laws; then repair the leak.
When returning cylinder to supplier, be sure valve is closed; then install valve outlet plug tightly. Never
place a compressed gas cylinder where it may become part of an electrical circuit.
RECOMMENDED EQUIPMENT: In semiconductor process gas and other suitable applications,
Praxair recommends the use of engineering controls such as gas cabinet enclosures, automatic gas panels
(used to purge systems on cylinder changeout), excess-flow valves throughout the gas distribution system,
double containment for the distribution system, and continuous gas monitors.
NOTE: Prior to using any plastics, confirm their compatibility with arsine.
MIXTURES: When you mix two or more gases or liquefied gases, you can create additional,
unexpected hazards. Obtain and evaluate the safety information for each component before you produce
the mixture. Consult an industrial hygienist or other trained person when you evaluate the end product.
Remember, gases and liquids have properties that can cause serious injury or death.
Product: Arsine P-4565-F Date: August 2000
HAZARD RATING SYSTEMS:
NFPA RATINGS: HMIS RATINGS:
=4 =4
HEALTH HEALTH
FLAMMABILITY FLAMMABILITY
=4 =4
REACTIVITY REACTIVITY
=2 =2
SPECIAL = None
STANDARD VALVE CONNECTIONS FOR U.S. AND CANADA:
CGA-350 connection is standard.
THREADED:
Not applicable
PIN-INDEXED YOKE:
ULTRA-HIGH-INTEGRITY CONNECTION: CGA-632
Use the proper CGA connections. DO NOT USE ADAPTERS. Additional limited-standard
connections may apply. See CGA pamphlet V-1 listed below.
Ask your supplier about free Praxair safety literature as referred to in this MSDS and on the label for this
product. Further information about this product can be found in the following pamphlets published by the
Compressed Gas Association, Inc. (CGA), 1725 Jefferson Davis Highway, Arlington, VA 22202-4102,
Telephone (703) 412-0900.
P-1 Safe Handling of Compressed Gases in Containers
V-1 Compressed Gas Cylinder Valve Inlet and Outlet Connections
?? Handbook of Compressed Gases, Fourth Edition
Praxair asks users of this product to study this MSDS and become aware of product hazards and safety
information. To promote safe use of this product, a user should (1) notify employees, agents, and
contractors of the information in this MSDS and of any other known product hazards and safety
information, (2) furnish this information to each purchaser of the product, and (3) ask each purchaser to
notify its employees and customers of the product hazards and safety information.
The opinions expressed herein are those of qualified experts within Praxair, Inc. We
believe that the information contained herein is current as of the date of this Material
Safety Data Sheet. Since the use of this information and the conditions of use of the
product are not within the control of Praxair, Inc., it is the user??s obligation to
determine the conditions of safe use of the product.
Praxair MSDSs are furnished on sale or delivery by Praxair or the independent distributors and suppliers
who package and sell our products. To obtain current Praxair MSDSs for these products, contact your
Praxair sales representative or local distributor or supplier. If you have questions regarding Praxair
MSDSs, would like the form number and date of the latest MSDS, or would like the names of the Praxair
suppliers in your area, phone or write the Praxair Call Center (Phone: 1-800-PRAXAIR;
Address: Praxair Call Center, Praxair, Inc., PO Box 44, Tonawanda, NY 14150-7891).
Praxair and the Flowing Airstream design are trademarks or registered trademarks of
Praxair Technology, Inc. in the United States and other countries.
Praxair, Inc.
39 Old Ridgebury Road
Danbury, CT 06810-5113
Printed in
;
Recommended suppliers