*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : SL6250000
CHEMICAL NAME : Phenol, 4,4'-isopropylidenebis(2,6-dichloro-
CAS REGISTRY NUMBER : 79-95-8
BEILSTEIN REFERENCE NO. : 2059573
REFERENCE : 3-06-00-05462 (Beilstein Handbook Reference)
LAST UPDATED : 199701
DATA ITEMS CITED : 6
MOLECULAR FORMULA : C15-H12-Cl4-O2
MOLECULAR WEIGHT : 366.07
WISWESSER LINE NOTATION : QR BG FG DX1&1&R DQ BG FG
COMPOUND DESCRIPTOR : Primary Irritant
SYNONYMS/TRADE NAMES :
* 2,2-Bis(3,5-dichloro-4-hydroxyphenyl)propane
* 2,2-Bis(4-hydroxy-3,5-dichlorophenyl)propane
* 4,4'-Isopropylidenebis(2,6-dichlorophenol)
* 4,4'-(1-Methylethylidene)bis(2,6-dichlorophenol)
* NSC 18248
* Phenol, 4,4'-(1-methylethylidene)bis(2,6-dichloro-
* Tetrachlordian
* 2,2',6,6'-Tetrachlorobisphenol A
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/24H
REACTION SEVERITY : Mild
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,536,1986
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 7432 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 49(2),64,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 5050 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 49(2),64,1984
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 67500 mg/kg/45D-I
TOXIC EFFECTS :
Blood - microcytosis with or without anemia
Blood - changes in erythrocyte (RBC) count
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 49(2),64,1984
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 9750 mg/kg/26W-I
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells
Blood - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 49(2),64,1984
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***
|