*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : PX4520050
CHEMICAL NAME : Metiram, methyl-
CAS REGISTRY NUMBER : 8064-35-5
LAST UPDATED : 199012
DATA ITEMS CITED : 9
COMPOUND DESCRIPTOR : Agricultural Chemical
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Basfungin
* Basfungine
* Methyl metiram
* Propylene bisdithiocarbamate
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd.
Russki 6, Sofia, Bulgaria) V.9- 1966- Volume(issue)/page/year:
20,515,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd,
eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year:
A275,1983
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 312 mg/kg
SEX/DURATION : female 1-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
DBANAD Doklady Bolgarskoi Akademii Nauk. (Hemus, Blvd. Russki 6, Sofia,
Bulgaria) V.1- 1948- Volume(issue)/page/year: 29,1227,1976
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 250 mg/kg
SEX/DURATION : female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
JHEMA2 Journal of Hygiene, Epidemiology, Microbiology, and Immunology.
(Avicenum, Malostranske namesti 28, 11802 Prague 1, Czechoslovakia) V.1-
1957- Volume(issue)/page/year: 24,295,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 250 mg/kg
SEX/DURATION : female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
JHEMA2 Journal of Hygiene, Epidemiology, Microbiology, and Immunology.
(Avicenum, Malostranske namesti 28, 11802 Prague 1, Czechoslovakia) V.1-
1957- Volume(issue)/page/year: 24,295,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 328 mg/kg
SEX/DURATION : female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
JHEMA2 Journal of Hygiene, Epidemiology, Microbiology, and Immunology.
(Avicenum, Malostranske namesti 28, 11802 Prague 1, Czechoslovakia) V.1-
1957- Volume(issue)/page/year: 24,295,1980
** MUTATION DATA **
TYPE OF TEST : Gene conversion and mitotic recombination
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 1000 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 10,533,1970
TYPE OF TEST : Dominant lethal test
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 1350 mg/kg/90D
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 46,240,1977
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
*** END OF RECORD ***
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