*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : FI0700000
CHEMICAL NAME : Carrageen
CAS REGISTRY NUMBER : 9000-07-1
OTHER CAS REGISTRY NOS. : 78005-48-8
LAST UPDATED : 199706
DATA ITEMS CITED : 11
COMPOUND DESCRIPTOR : Tumorigen
Natural Product
SYNONYMS/TRADE NAMES :
* Aubygel GS
* Aubygum DM
* Burtonite V-40-E
* Carastay
* Carastay C
* Carrageenan
* Carrageenan gum
* Carrageenin
* Carragheen
* Carragheenan
* Colloid 775
* Coreine
* Eucheuma spinosum gum
* Flanogen ELA
* Galozone
* Gelcarin
* Gelcarin HWG
* Gelozone
* Genugel
* Genugel CJ
* Genugol RLV
* Genuvisco J
* Gum carrageenan
* Gum chon 2
* Gum chond
* Killeen
* Lygomme CDS
* Norsk gelatan
* Pearlpuss
* Pellugel
* Pellugel ID
* Pencogel
* Pig-Wrack
* Satiagel GS350
* Satiagum 3
* Satiagum standard
* Seakem carrageenin
* Soa Ace WX 138
* Viscarin TP 389
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 5 mg/kg
TOXIC EFFECTS :
Blood - change in clotting factors
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
Volume(issue)/page/year: 17,647,1965
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 20 mg/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 202,401,1964
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2100 gm/kg/40W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - colon tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
38,4427,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 525 mg/kg/21W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
13BYAH "Morphological Precursors of Cancer, Proceedings of an International
Conference, Perugia, Italy, 1961," Severi, L., ed., Perugia, Univ. of
Perugia, 1962 Volume(issue)/page/year: -,83,1962
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 430 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year:
15,607,1961
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 320 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 32,711,1986
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 10,181,1976
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 84153
No. of Facilities: 460 (estimated)
No. of Industries: 7
No. of Occupations: 11
No. of Employees: 7864 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 84153
No. of Facilities: 1064 (estimated)
No. of Industries: 9
No. of Occupations: 24
No. of Employees: 42680 (estimated)
No. of Female Employees: 17454 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***
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