*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : OB8880000
CHEMICAL NAME : Kinase (enzyme-activating), strepto-
CAS REGISTRY NUMBER : 9002-01-1
LAST UPDATED : 199512
DATA ITEMS CITED : 7
COMPOUND DESCRIPTOR : Drug
Human
Natural Product
SYNONYMS/TRADE NAMES :
* Awelysin
* Kabikinase
* Streptase
* Streptococcal fibrinolysin
* Streptokinase
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Human
DOSE/DURATION : 600 iu/kg
TOXIC EFFECTS :
Immunological Including Allergic - uncharacterized
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year:
252,1314,1984
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Human - man
DOSE/DURATION : 562500 iu/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year:
252,1314,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 43,671,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FOHEAW Folia Haematologica (Leipzig). (Buchexport, Postfach 160, Leipzig
DDR-7010, Ger. Dem. Rep.) V.32- 1926- Volume(issue)/page/year:
103,445,1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FOHEAW Folia Haematologica (Leipzig). (Buchexport, Postfach 160, Leipzig
DDR-7010, Ger. Dem. Rep.) V.32- 1926- Volume(issue)/page/year:
103,445,1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 3700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 43,671,1980
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4087
No. of Facilities: 41 (estimated)
No. of Industries: 1
No. of Occupations: 5
No. of Employees: 9366 (estimated)
No. of Female Employees: 8266 (estimated)
*** END OF RECORD ***
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