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Deaminase, adenosine

MATERIAL SAFETY DATA SHEET

I IDENTIFICATION
PRODUCT: ADA

MANUFACTURER: BioVectra dcl
16 McCarville St.
West Royalty Industrial Park
Char lotte town, P.E. I.
C1E 2A6
(902)566-1396

EMERGENCY TELEPHONE NO.: CANUTEC 613-996-6666
CHEMICAL NAME: Adenosine Deaminase
CATALOGUE NUMBER: A-020
TSCA STATUS: Th is materi als is a rea gent used to manuf acture a drug and as such is not su bject to TSCA.
PRODUCT USE: Enzyme catalyst
II HAZARDOUS INGREDIENTS
Adenosine deaminase precipitate in 70% ammonium sulphate solution. CAS No. adenosine deaminase 9026-93-1
Enzyme Source = Beef sp leen
Ammonium sulphate CAS No. 7783-20-2

III TOXICOLOGICAL PROPERTIES
VI REACTIVITY
EFFECTS OF ACUTE EXPOSURE
Routes of Entry Skin Contact [x] Eye Contact [x] STABILITY: Stable
Skin Absorption [x] Inhalation [x] Ingestion [x]
EYES: May cause irritation. INCOMPATIBILITY: Ammonium sulphate - oxidizers.
SKIN: May cause irritation, may be absorbed.
INHALATION: May cause irritation, may be harmful. HAZARDOUS DECOMPOSITION PRODUCTS: Ammonia,
INGESTION: May be harmful. sulphur trioxide and sulphur dioxide gases.
CHRONIC HEALTH HAZARDS: Prolonged or repeated
exposure to adenosine deaminase may cause an allergic HAZARDOUS POLYMERIZATION: Will not occur.
reaction in certain sensitive individuals.
EVIDENCE OF CARCINOGENICITY, TERATOGENICITY, VII PHYSICAL DATA
REPRODUCTIVE TOXICITY, MUTAGENICITY: No data
available PHYSICAL STATE: Particulates suspended in solution.
SYNERGISTIC PRODUCTS: Not available APPEARANCE AND Off white powder in suspended clear
SENSITIZATION TO PRODUCT: Not available solution.
IRRITANCY OF PRODUCT: Not available ODOUR THRESHOLD: Not available
EXPOSURE LIMITS: TLV 10 ppm ACGIH MELTING POINT: n.av..
LD50: Ammoni um sul phat e oral ra t 300 0 mg/k g, hum an TDLo BOILING POINT: Ammonium sulphat e - 235?? C
1.5 g/kg. SPECIFIC GRAVITY: Ammonium sulphate - 1.77
VAPOUR PRESSURE: Not available
IV FIRST AID MEASURES VAPOUR DENSITY: Not available
WATER SOLUBILITY: Enzyme is water soluble
EVAPORATION RATE: Not available
EYES: Flush eyes with water for at least 15 mi nutes and get
pH: Ammonium sulphate solution 7
medical attention.
COEFFICIENT OF OIL/WATER: Not available
SKIN: In case of contact, immediately flush area with plenty of
water.
INHALATION: If inhaled, remove victim to fresh air. If not VIII PREVENTIVE MEASURES
breathing, give artificial respiration. If breathing is difficult,
give oxygen and obtain medical attention. PERSONAL PROTECTIVE EQUIPMENT: Lab coat, safety
INGESTION: If ingested, drink plenty of fluids and obtain goggles, and rubber gloves.
medical attention.
VENTILATION: General exhaust
V FIRE AND EXPLOSION HAZARDS
RESPIRATORY PROTECTION: None normally required.
FLAMMABLE: No
LEAK AND SPILL PROCEDURES: Ventilate the area. Wear
FLASH POINT: Not applicable
appropriate personal protective equipment. Absorb material
FLAMMABLE LIMITS (% in air):
spilled material and wipe down spill area with plenty of soap
Lower: Not applicable
and water.
Upper: Not applicable
EXTINGUISHING MEDIA: Water spray, carbon dioxide, dry
WASTE DISPOSAL: Burn in chemical incinerator. Observe all
chemical, or foam.
federal, provincial, state and local regulations.
AUTOIGNITION TEMPERATURE: Not available
HAZARDOUS COMBUSTION PRODUCTS: n.av..
OTHER PRECAUTIONS: Avoid contact. Do not get in eyes,
EXPLOSION DATA: Sensitivity to mechanical impact, not
on skin, or clothing. Wash thoroughly after handling. Wash
available. Sens itivity to stat ic discharg e, not availab le.
contamina ted clothing b efore reuse.
VIII PREVENTIVE MEASURES (Continued)

STORAGE REQUIREMENTS: 2 -8??C

SPECIAL SHIPPING INFORMATION: Not regulated.

LABEL PRECAUTIONARY STATEMENTS: Caution:
Prolonged or repeated exposure may cause allergic reactions in
certain sensitive individuals. Avoid eye and skin contact.
Avoid inhalation and ingestion.

IX PREPARATION OF MSDS

PREPARED BY: Jeremy Stiles
DATE: February 26, 2001
Phone Number: 902-566-1396

*n.av.. not available n.ap. not applicable

This material is for use as a reagent in pharmaceutical
manufacturing. As it is sold for use as a pharmaceutical
reagent only, it is not required to appear in the TSCA
inventory.

The information provided on this Material Safety Data Sheet
is provided in the interest of promoting safe handling of the
material. While this information is believed to be correct, DCL
makes no warranty in respect to any of the information
disclosed. Observe all federal, provincial, state and local laws
concerning health and pollution.

msdsA-020-2

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