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Magnesium,bromo(1-methylethyl)-

MSDS Ref. No: QS-MSD-228
Version: US/Canada
Date Approved: 02/01/07
Revision No: 1

1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
Isopropylmagnesium bromide in diethyl ether.
PRODUCT NAME:
Grignard reagent
CHEMICAL FAMILY:
C3H7 Mg Br
MOLECULAR FORMULA:
Industrial Manufacturing.
GENERAL USE:

MANUFACTURER Emergency Telephone Numbers:
FMC CORPORATION CHEMTREC (800) 424-9300
Lithium Division Emergency Phone (704) 629-5361 (Plant) Call
P.O. Box 795 Collect 24 Hr/Day
Bessemer City, NC 28016-0795 Emergency Phone (303) 595-9048 (Medical)
General Information: (704) 868-5300 Call Collect

2. COMPOSITION / INFORMATION ON INGREDIENTS

Chemical Name CAS # Wt.%
isopropylmagnesium bromide 920-39-8 18-35
diethyl ether 60-29-7 65-82

3. HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Flammable liquid. Water reactive. In case of fire do not use water or
IMMEDIATE CONCERNS:
carbon dioxide. Faintly turbid gray liquid.
Corrosive to the eyes (may cause blindness), skin, mucous
POTENTIAL HEALTH EFFECTS:
membranes and upper respiratory tract. Inhalation of vapors may
cause dizziness, nausea, anesthesia, numbness, motor weakness
in fingers and toes, incoordination, and headache.

COMMENTS:
(See Section 11, Toxicological Information)

4. FIRST AID MEASURES
Immediately flush with water for at least 15 minutes, lifting the
EYES:
upper and lower eyelids intermittently. See a medical doctor or
ophthalmologist immediately.
Quickly wipe off as much as possible, then immediately flush with
SKIN:
plenty of water while removing contaminated clothing and/or shoes.
Thoroughly wash with soap and water. Obtain immediate medical
attention. Contact a medical doctor if necessary.
Quickly wipe material from the mouth and rinse mouth with water.
INGESTION:
Do not induce vomiting. Never give anything by mouth to an
unconscious person. See a medical doctor immediately.
Remove to fresh air. If breathing discomfort occurs and persists,
INHALATION:
see a medical doctor. If breathing has stopped, give artificial
MSDS Ref. No: QS-MSD-228
Version: US/Canada
Date Approved: 02/01/07
Revision No: 1
respiration and see a medical doctor immediately.
NOTES TO MEDICAL DOCTOR:
This product is corrosive to eyes, skin, and mucous membranes. Consideration should be given to careful endoscopy
as stomach or esophageal burns, perforations or strictures may occur. Careful gastric lavage with an endotracheal
tube in place should be considered. Observation may be warranted. Treatment is controlled removal of exposure
followed by symptomatic and supportive care.

5. FIRE FIGHTING MEASURES
Upper: 36% Lower: 1.7% (diethyl ether)
FLAMMABLE LIMITS:
Flammable liquid. Reacts violently with water to give off flammable
GENERAL HAZARD:
fumes and corrosive dust.
DO NOT USE WATER OR CARBON DIOXIDE. Use dry chemical.
EXTINGUISHING MEDIA:
Magnesium hydroxide, carbon dioxide, carbon monoxide.
HAZARDOUS COMBUSTION PRODUCTS:
Wear full protective clothing and self-contained breathing apparatus
FIRE FIGHTING PROCEDURES:
(SCBA) approved for fire fighting. This is necessary to protect against
the hazards of heat, products of combustion and oxygen deficiency.
Do not breathe smoke, gases or vapors generated.
Not applicable
AUTOIGNITION TEMPERATURE:
Water reactivity and volatility of solvents.
PROPERTIES CONTRIBUTING TO
FLAMMABILITY:
-45 oC (diethyl ether)
FLASH POINT:
Yes
SENSITIVITY TO STATIC DISCHARGE:
None
SENSITIVITY TO IMPACT:

COMMENTS:
(See Section 10, Stability and Reactivity)
6. ACCIDENTAL RELEASE MEASURES
Remove all sources of ignition. Do not use water in the initial phases
RELEASE NOTES:
of clean up. Contain spill with absorbent. Transfer to approved
transport container and clean up spillage with an absorbent. Dispose
of waste according to local and Federal laws and regulations.
Before cleanup measures begin, review the entire MSDS with
particular attention to Section 3, Emergency Overview and Potential
Health Effects; and Section 8, Recommended Personal Protective
Equipment.

7. HANDLING AND STORAGE
Use in a closed system under argon or nitrogen. Do not get in eyes,
HANDLING:
on skin or clothing. Do not breathe vapors or mist.
Store in a cool place. Storage temperature should be kept below 30
STORAGE:
oC. Keep container closed. Keep away from sources of ignition,
water, air, acids and oxidizing agents.

8. EXPOSURE CONTROLS / PERSONAL PROTECTION
EXPOSURE LIMITS
Chemical Name TWA STEL/Ceiling PEL STEL/Ceiling
(ACGIH) (ACGIH) (OSHA) (OSHA)
diethyl ether 400 ppm 500 ppm 400 ppm
MSDS Ref. No: QS-MSD-228
Version: US/Canada
Date Approved: 02/01/07
Revision No: 1
ENGINEERING CONTROLS:

Use in closed system under argon or nitrogen. If personal contact can occur, use local exhaust ventilation (explosion-
proof), to keep airborne concentrations below exposure limits.

PERSONAL PROTECTIVE EQUIPMENT
Chemical splash goggles with a face shield.
Eyes And Face:

When engineering controls are not adequate, wear a NIOSH/MSHA
Respiratory:
respirator approved for protection against organic vapors and mists.

Rubber gloves and rubber clothing.
Protective Clothing:

Quick-drench eyewash and safety shower.
Work Hygienic Practices:

9. PHYSICAL AND CHEMICAL PROPERTIES
That of diethyl ether
ODOR:
Grey, faintly turbid liquid
APPEARANCE:
Not applicable
pH:
65-80 %
PERCENT VOLATILE:
59 kPa (442 mm Hg) at 20 oC (diethyl ether)
VAPOR PRESSURE:
(Air = 1): 2.56 (diethyl ether)
VAPOR DENSITY:
34.5 oC (diethyl ether)
BOILING POINT:
Not applicable.
MELTING POINT:
Product reacts with water. Diethyl ether is moderately soluble (6.5-
SOLUBILITY IN WATER:
6.9 g/100 g water at 25 deg C)
11.1-11.8 (diethyl ether)
EVAPORATION RATE(Butyl Acetate = 1):
0.86 g/cc
SPECIFIC GRAVITY:
74.80
MOLECULAR WEIGHT:
Not applicable
COEFF. OIL/WATER:
Not available
ODOR THRESHOLD:
Upper: 36% Lower: 1.7% (diethyl ether)
FLAMMABLE LIMITS:
-45 oC (diethyl ether)
FLASH POINT:
Not available.
AUTOIGNITION TEMPERATURE:
Not applicable.
EXPLOSIVE PROPERTIES:
Not applicable.
OXIDIZING PROPERTIES:

10. STABILITY AND REACTIVITY
Water, heat, sparks, open flame, and air.
CONDITIONS TO AVOID:
Stable at room temperature.
STABILITY:
Does not polymerize
POLYMERIZATION:
none
HAZARDOUS DECOMPOSITION
PRODUCTS:
Acids, alcohols, oxidizers, oxygen, heat, sparks, water and open
INCOMPATIBLE MATERIALS:
flame.

11. TOXICOLOGICAL INFORMATION
No data available for the product.
Eye Contact:
isopropylmagnesium bromide: Corrosive
MSDS Ref. No: QS-MSD-228
Version: US/Canada
Date Approved: 02/01/07
Revision No: 1
No data available for the product.
Skin Contact:
isopropylmagnesium bromide: Corrosive

No data available for the product.
Skin Absorption:
diethyl ether: Dermal LD = >20 mL/kg (rabbit) [RTECS 2006]
50
No data available for the product.
Ingestion:
diethyl ether: Oral LD = 1215 mg/kg (rat) [RTECS 2006]
50
No data available for the product.
Inhalation:
diethyl ether: Inhalation LC = 31000 ppm/30M (mouse)
50
[RTECS 2006]

Acute Effects From Overexposure:
No data available for the product. This product is corrosive to skin, eyes (may cause blindness), mucous membranes
and upper respiratory tract. Inhalation of vapors may cause dizziness, nausea, anesthesia, numbness, burning
sensation and motor weakness in fingers and toes, incoordination, and headache. Low viscosity material--if
swallowed may enter the lungs and cause lung damage.

Chronic Effects From Overexposure:
No data available for the product.

Diethyl ether: Prolonged contact with diethyl ether may cause defatting of the skin and skin irritation.

No data available for the product.
Sensitization:
EH40: Not listed.
Carcinogenicity:
IARC: Not listed.
NTP: Not listed.
OSHA: Not considered a carcinogen under OSHA.
OTHER: ACGIH: Not listed

No data available for the product.
Mutagenicity:
.
No data available for the product.
Reproductive Toxicity:

12. ECOLOGICAL INFORMATION

Ecotoxicological Information:
Environmental toxicity testing of the product has not been carried out.
diethyl ether:
96h LC50 = 2600 mg/L (fathead minnow) [Handbook Env. Data on Org. Chem., 4th Ed]
48h LC50 = 2800 mg/L (golden orfe) [Handbook Env. Data on Org. Chem., 4th Ed]

Chemical Fate Information:
No data available for the product. isopropylmagnesium bromide reacts violently with water to form propane and
magnesium hydroxide.

13. DISPOSAL CONSIDERATIONS
Dispose of waste according to local and Federal laws and regulations.
DISPOSAL METHOD:

14. TRANSPORT INFORMATION
MSDS Ref. No: QS-MSD-228
Version: US/Canada
Date Approved: 02/01/07
Revision No: 1

Organometallic substance, liquid, water-reactive, flammable
PROPER SHIPPING NAME:
(isopropylmagnesium bromide, ether, solution)
Dangerous when wet, 4.3 (3, Flammable liquid)
CLASSIFICATION:
Dangerous when wet, Flammable
LABELS:
UN3399
UN NUMBER:
I
PACKING GROUP:
2931.00.9160
CUSTOM TARIFF NO:
No
MARINE POLLUTANT:
Not designated Poison Inhalation Hazard by US DOT.
PIH:

15. REGULATORY INFORMATION

UNITED STATES
SECTION 311 HAZARD CATEGORY (40 CFR 370): Fire hazard, immediate (acute) health hazard, reactive
This product does not contain a toxic chemical subject to the
SECTION 313 REPORTABLE INGREDIENTS (40
reporting requirements of Section 313 of Emergency
CFR 372):
Planning and Community Right-To-Know Act of 1986.
SECTION 302 EXTREMELY HAZARDOUS
SUBSTANCES (40 CFR 355): Not listed
CERCLA HAZARDOUS SUBSTANCE (40 CF 302.4): Diethyl ether is listed. The reportable quantity is 100 lbs.
TSCA SEC 12B EXPORT NOTIFICATION: This product is not subject to TSCA 12 (b) Export
Notification Requirements.
TSCA INVENTORY STATUS (40 CFR 710): Listed.

Product Identification No.: 3399
CANADA
Hazard Classification: Class B, Division 2 (Flammable liquid)
WHMIS:
Class B, Division 6 (Reactive Flammable Materials)
Class E, (Corrosive)
Ingredient Disclosure List: Diethyl ether is listed.

16. OTHER INFORMATION

REVISION SUMMARY: Revision #1: Section 14 revised.
NFPA RATING HEALTH: 3
FLAMMABILITY: 4
REACTIVITY: 2
SPECIAL: W

This MSDS has been prepared to meet U. S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and
Canada's Workplace Hazardous Materials Information System (WHMIS) requirements.
type 2c
Copyright 2007. FMC Corporation, Lithium Division. All Rights Reserved. FMC Lithium and the FMC Lithium logo
are trademarks of FMC Corporation.

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