Ademetionine disulfate tosylate

MSDS

 Adenosine,
5'-((3-amino-3-carboxypropyl)methylsulfonio)-5'-deoxy
-, (S)-, salt with 4-methylbenzenesulfonic acid,
sulfate (salt) (1:1:2)

CAS

 97540-22-2

SYNONYMS

 * S-Adenosyl-L-methionine sulfate tosylate
* FO-1561

Catalog of Chemical Suppliers, Buyers, Custom Synthesis Companies And Equipment Manufacturers
[ Adenosine,5'-((3-amino-3-carboxypropyl)methylsulfonio)-5'-deoxy-, (S)-, salt with 4-methylbenzenesulfonic acid,sulfate (salt) (1:1:2) 97540-22-2 ]

                     *** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AU7334500
CHEMICAL NAME           : Adenosine,
                          5'-((3-amino-3-carboxypropyl)methylsulfonio)-5'-deoxy
                          -, (S)-, salt with 4-methylbenzenesulfonic acid,
                          sulfate (salt) (1:1:2)
CAS REGISTRY NUMBER     : 97540-22-2
OTHER CAS REGISTRY NOS. : 110899-33-7
LAST UPDATED            : 199206
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C15-H23-N6-O5-S.H-O4-S.H2-O4-S.C7-H8-O3-S
MOLECULAR WEIGHT        : 766.86
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * S-Adenosyl-L-methionine sulfate tosylate
   * FO-1561
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3320 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - convulsions or effect on seizure threshold
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 15,4471,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2579 mg/kg
TOXIC EFFECTS :
   Blood - normocytic anemia
   Skin and Appendages - hair
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 15,4471,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 998 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 15,4471,1987
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 8100 mg/kg/90D-C
TOXIC EFFECTS :
   Cardiac - changes in heart weight
   Liver - changes in liver weight
   Endocrine - changes in adrenal weight
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 15,4481,1987
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10950 mg/kg/52W-C
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - other changes in urine composition
   Kidney, Ureter, Bladder - other changes
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 15,4507,1987
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 7 gm/kg/35D-C
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - urine volume increased
   Blood - other changes
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - phosphatases
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 16,1927,1988
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 73 gm/kg/52W-C
TOXIC EFFECTS :
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
   Nutritional and Gross Metabolic - changes in sodium
   Nutritional and Gross Metabolic - changes in potassium
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 16,1955,1988
 
                            *** END OF RECORD ***

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