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Thymidine,5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[2-cyanoethylN,N-bis(1-methylethyl)phosphoramidite]

MSDS Number: P4004 * * * * * Effective Date: 11/17/99 * * * * * Supercedes: 12/08/96

MSDS MATERIAL SAFETY DATA SHEET CHEMTREC: 800-424-9300 (USA)
------------------------------------------ 703-527-3887(Outside USA and
Canada)
CANUTEC: 613-996-6666
From: Mallinckrodt Baker, Inc
222 Red School Lane
Phillipsburg, NJ 08865 NOTE: Use CHEMTREC and CANUTEC
phone numbers only in the event
Emergency Telephone Number: 908-859-2151 of a chemical emergency.

All non-emergency questions should be directed to Customer Service (1-800-582-2537) for
assistance.

MALLINCKRODT

dT-CE PHOSPHORAMIDITE

1. Product Identification
Synonyms: 5'-Dimethoxytrityl-2'-deoxyThymidine, 3'-[(2-cyanoethyl)-(N,N-
diisopropyl)]-phosphoramidite; CED Phophoramidites
CAS No.: 98796-51-1
Molecular Weight: 744.83
Chemical Formula: C40H49N4O8P
Product Codes: V210

2. Composition/Information on Ingredients
Ingredient CAS No Percent Hazardous
--------------------------------------- ------------ ------- ---------

dT-CE Phosphoramidite 98796-51-1 100% Yes
3. Hazards Identification
Emergency Overview
--------------------------
WARNING! MAY BE HARMFUL IF SWALLOWED, INHALED OR ABSORBE THROUGH SKIN. MAY CAUSE IRRITATION TO SKIN, EYES, AN RESPIRATORY TRACT.

Potential Health Effects
----------------------------------

Information on the human health effects from exposure to this substance is limited.

Inhalation:
May be harmful if inhaled. Inhalation of dust may be irritating to the respiratory tract.
Ingestion:
May be harmful if swallowed.
Skin Contact:
May cause irritation.
Eye Contact:
May cause irritation.
Chronic Exposure:
No information found.
Aggravation of Pre-existing Conditions:
No information found.

4. First Aid Measures
Inhalation:
Remove to fresh air. Get medical attention for any breathing difficulty.
Ingestion:
Induce vomiting immediately as directed by medical personnel. Never give anything by
mouth to an unconscious person. Get medical attention.
Skin Contact:
Remove any contaminated clothing. Wash skin with soap or mild detergent and water for
at least 15 minutes. Get medical attention if irritation develops or persists.
Eye Contact:
Wash thoroughly with running water. Get medical advice if irritation develops.
5. Fire Fighting Measures
Fire:
As with most organic solids, fire is possible at elevated temperatures or by contact with
an ignition source.
Explosion:
Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition
source is a potential dust explosion hazard.
Fire Extinguishing Media:
Water spray, dry chemical, alcohol foam, or carbon dioxide.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained
breathing apparatus with full facepiece operated in the pressure demand or other positive
pressure mode.

6. Accidental Release Measures
Remove all sources of ignition. Ventilate area of leak or spill. Wear appropriate personal
protective equipment as specified in Section 8. Spills: Clean up spills in a manner that
does not disperse dust into the air. Use non-sparking tools and equipment. Reduce
airborne dust and prevent scattering by moistening with water. Pick up spill for recovery
or disposal and place in a closed container.

7. Handling and Storage
Isolate from incompatible substances. Store at 2-4C

8. Exposure Controls/Personal Protection
Airborne Exposure Limits:
None established.
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee exposures as
low as possible. Local exhaust ventilation is generally preferred because it can control
the emissions of the contaminant at its source, preventing dispersion of it into the general
work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of
Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):
For conditions of use where exposure to the dust or mist is apparent, a half-face dust/mist
respirator may be worn. For emergencies or instances where the exposure levels are not
known, use a full-face positive-pressure, air-supplied respirator. WARNING: Air-
purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection:
Wear protective gloves and clean body-covering clothing.
Eye Protection:
Use chemical safety goggles. Maintain eye wash fountain and quick-drench facilities in
work area.

9. Physical and Chemical Properties
Appearance:
White to off-white free flowing powder.
Odor:
Odorless.
Solubility:
Insoluble in water.
Specific Gravity:
ca. 1
pH:
No information found.
% Volatiles by volume @ 21C (70F):
No information found.
Boiling Point:
Decomposes.
Melting Point:
No information found.
Vapor Density (Air=1):
No information found.
Vapor Pressure (mm Hg):
No information found.
Evaporation Rate (BuAc=1):
No information found.

10. Stability and Reactivity
Stability:
Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products:
Burning may produce carbon monoxide, carbon dioxide, nitrogen oxides.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Strong oxidizers.
Conditions to Avoid:
No information found.

11. Toxicological Information
--------\Cancer Lists\------------------------------------------------------
---NTP Carcinogen---
Ingredient Known Anticipated IARC Category
------------------------------------ ----- ----------- -------------
dT-CE Phosphoramidite (98796-51-1) No No None

12. Ecological Information
Environmental Fate:
No information found.
Environmental Toxicity:
No information found.

13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be managed in an appropriate
and approved waste disposal facility. Processing, use or contamination of this product
may change the waste management options. State and local disposal regulations may
differ from federal disposal regulations. Dispose of container and unused contents in
accordance with federal, state and local requirements.

14. Transport Information
Not regulated.

15. Regulatory Information
--------\Chemical Inventory Status - Part 1\--------------------------------
-
Ingredient TSCA EC Japan Australia
----------------------------------------------- ---- --- ----- ---------
dT-CE Phosphoramidite (98796-51-1) Exempt No No No

--------\Chemical Inventory Status - Part 2\--------------------------------
-
--Canada--
Ingredient Korea DSL NDSL Phil.
----------------------------------------------- ----- --- ---- -----
dT-CE Phosphoramidite (98796-51-1) No No No No

--------\Federal, State & International Regulations - Part 1\---------------
-
-SARA 302- ------SARA 313-----
-
Ingredient RQ TPQ List Chemical
Catg.
----------------------------------------- --- ----- ---- -------------
-
dT-CE Phosphoramidite (98796-51-1) No No No No

--------\Federal, State & International Regulations - Part 2\---------------
-
-RCRA- -TSCA-
Ingredient CERCLA 261.33 8(d)
----------------------------------------- ------ ------ ------
dT-CE Phosphoramidite (98796-51-1) No No No

Chemical Weapons Convention: No TSCA 12(b): No CDTA: No
SARA 311/312: Acute: Yes Chronic: No Fire: No Pressure: No
Reactivity: No (Pure / Solid)

Australian Hazchem Code: No information found.
Poison Schedule: No information found.
WHMIS:
This MSDS has been prepared according to the hazard criteria of the Controlled Products
Regulations (CPR) and the MSDS contains all of the information required by the CPR.

16. Other Information
NFPA Ratings: Health: 1 Flammability: 1 Reactivity: 0
Label Hazard Warning:
WARNING! MAY BE HARMFUL IF SWALLOWED, INHALED OR ABSORBE THROUGH SKIN. MAY CAUSE IRRITATION TO SKIN, EYES, AN RESPIRATORY TRACT.
Label Precautions:
Avoid breathing dust.
Avoid contact with eyes, skin and clothing.
Keep container closed.
Use with adequate ventilation.
Wash thoroughly after handling.
INTENDED FOR R & D USE ONLY.
NOT ON THE TSCA INVENTORY.
Label First Aid:
If swallowed, call a physician immediately. If inhaled, remove to fresh air. Get medical
attention for any breathing difficulty. In case of contact, immediately flush eyes or skin
with plenty of water for at least 15 minutes.
Product Use:
Research and Development Use Only.
Revision Information:
No changes.
Disclaimer:
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Mallinckrodt Baker, Inc. provides the information contained herein in good faith
but makes no representation as to its comprehensiveness or accuracy. This
document is intended only as a guide to the appropriate precautionary handling of
the material by a properly trained person using this product. Individuals receiving
the information must exercise their independent judgment in determining its
appropriateness for a particular purpose. MALLINCKRODT BAKER, INC.
MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS O IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF
MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE WITH
RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT
TO WHICH THE INFORMATION REFERS. ACCORDINGLY,
MALLINCKRODT BAKER, INC. WILL NOT BE RESPONSIBLE FO DAMAGES RESULTING FROM USE OF OR RELIANCE UPON THIS
INFORMATION.
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Prepared by: Strategic Services Division
Phone Number: (314) 654-1600 (U.S.A.)

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