5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-[(carboxymethoxy)imino]acetyl]amino]-3-ethenyl-8-oxo-,hydrate (1:3), (6R,7R)-

1. 1.1 IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING Product identifiers Product name Product Number Brand CAS-No. : : : : Cefixime Trihydrate 18588 Fluka 125110-14-7 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Manufacture of substances 2. 2.1 2.2 HAZARDS IDENTIFICATION Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP] Respiratory sensitization (Category 1) Skin sensitization (Category 1) Classification according to EU Directives 67/548/EEC or 1999/45/EC May cause sensitization by inhalation and skin contact. Label elements Labelling according Regulation (EC) No 1272/2008 [CLP] Pictogram Signal word Hazard statement(s) H317 H334 Precautionary statement(s) P261 P280 P342 + P311 Supplemental Hazard Statements Danger May cause an allergic skin reaction. May cause allergy or asthma symptoms or breathing difficulties if inhaled. Avoid breathing dust. Wear protective gloves. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/ physician. none According to European Directive 67/548/EEC as amended. Hazard symbol(s) R-phrase(s) R42/43 S-phrase(s) S22 S36/37 S45 May cause sensitization by inhalation and skin contact. Do not breathe dust. Wear suitable protective clothing and gloves. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Caution - substance not yet tested completely. 2.3 3. 3.1 Other hazards - none COMPOSITION/INFORMATION ON INGREDIENTS Substances Synonyms Formula Molecular Weight Component Cefixime trihydrate : : : Cefiximetrihydrate C16H15N5O7S2??3H2O 507,50 g/mol Concentration CAS-No. 125110-14-7 - 4. 4.1 4.2 4.3 5. 5.1 FIRST AID MEASURES Description of first aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Flush eyes with water as a precaution. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. Most important symptoms and effects, both acute and delayed Gastrointestinal disturbance, hypersensitivity reactions, neutropenia, Elevated:, Increased liver enzymes., blood urea nitrogen, Nausea, Vomiting, Diarrhoea, Rash, Headache, Dizziness, Because of the similarity in structure of the penicillins and cephalosporins, those who are allergic to one class of agents may manifest cross-allergenicity when a member of the other class is encountered. Indication of any immediate medical attention and special treatment needed no data available FIREFIGHTING MEASURES Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. 5.2 5.3 5.4 6. 6.1 6.2 6.3 6.4 7. 7.1 7.2 7.3 8. 8.1 8.2 Special hazards arising from the substance or mixture Carbon oxides, nitrogen oxides (NOx), Sulphur oxides Advice for firefighters Wear self contained breathing apparatus for fire fighting if necessary. Further information no data available ACCIDENTAL RELEASE MEASURES Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions Do not let product enter drains. Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal. Reference to other sections For disposal see section 13. HANDLING AND STORAGE Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Air sensitive. Specific end uses no data available EXPOSURE CONTROLS/PERSONAL PROTECTION Control parameters Components with workplace control parameters Exposure controls Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Personal protective equipment Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). 9. 9.1 PHYSICAL AND CHEMICAL PROPERTIES Information on basic physical and chemical properties a) b) c) d) e) f) g) h) Appearance Odour Odour Threshold pH Melting point/freezing point Initial boiling point and boiling range Flash point Evaporation rate Form: powder Colour: light yellow no data available no data available 2,6 - 4,1 no data available no data available no data available no data available i) Flammability (solid, gas) no data available j) k) l) Upper/lower flammability or explosive limits Vapour pressure Vapour density no data available no data available no data available m) Relative density no data available n) o) p) q) r) s) t) Water solubility Partition coefficient: n- octanol/water Autoignition temperature Decomposition temperature Viscosity Explosive properties Oxidizing properties slightly soluble no data available no data available no data available no data available no data available no data available 9.2 10. 10.1 10.2 10.3 10.4 Other safety information no data available STABILITY AND REACTIVITY Reactivity no data available Chemical stability no data available Possibility of hazardous reactions no data available Conditions to avoid no data available 10.5 10.6 11. 11.1 Incompatible materials Strong oxidizing agents Hazardous decomposition products Other decomposition products - no data available TOXICOLOGICAL INFORMATION Information on toxicological effects Acute toxicity no data available Skin corrosion/irritation no data available Serious eye damage/eye irritation no data available Respiratory or skin sensitization no data available May cause allergic respiratory and skin reactions Germ cell mutagenicity no data available Carcinogenicity IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity no data available Specific target organ toxicity - single exposure no data available Specific target organ toxicity - repeated exposure no data available Aspiration hazard no data available Potential health effects Inhalation Ingestion Skin Eyes May be harmful if inhaled. May cause respiratory tract irritation. May be harmful if swallowed. May be harmful if absorbed through skin. May cause skin irritation. May cause eye irritation. Signs and Symptoms of Exposure Gastrointestinal disturbance, hypersensitivity reactions, neutropenia, Elevated:, Increased liver enzymes., blood urea nitrogen, Nausea, Vomiting, Diarrhoea, Rash, Headache, Dizziness, Because of the similarity in structure of the penicillins and cephalosporins, those who are allergic to one class of agents may manifest cross-allergenicity when a member of the other class is encountered. Additional Information RTECS: Not available 12. 12.1 12.2 12.3 ECOLOGICAL INFORMATION Toxicity no data available Persistence and degradability no data available Bioaccumulative potential no data available 12.4 12.5 12.6 13. 13.1 14. 14.1 Mobility in soil no data available Results of PBT and vPvB assessment no data available Other adverse effects no data available DISPOSAL CONSIDERATIONS Waste treatment methods Product Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Contaminated packaging Dispose of as unused product. TRANSPORT INFORMATION UN number 14.2 14.3 14.4 14.5 14.6 15. ADR/RID: - UN proper shipping name ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Not dangerous goods Transport hazard class(es) ADR/RID: - Packaging group ADR/RID: - Environmental hazards ADR/RID: no Special precautions for user no data available REGULATORY INFORMATION IMDG: - IMDG: - IMDG: - IMDG Marine pollutant: no IATA: - IATA: - IATA: - IATA: no This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006. 15.1 15.2 16. Safety, health and environmental regulations/legislation specific for the substance or mixture no data available Chemical Safety Assessment no data available OTHER INFORMATION Further information The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information this document is based on the resent state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Lookchem shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale.

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