*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : XI0192000
CHEMICAL NAME : 4-Thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic
acid, 3-(((aminocarbonyl)oxy)methyl)-6-
(1-hydroxyethyl)-7-oxo-, (acetyloxy)methyl ester,
(5R-(5-alpha,6-alpha(R*)))-
CAS REGISTRY NUMBER : 87238-52-6
BEILSTEIN REFERENCE NO. : 4723315
LAST UPDATED : 199612
DATA ITEMS CITED : 5
MOLECULAR FORMULA : C13-H16-N2-O8-S
MOLECULAR WEIGHT : 360.37
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* Acetoxymethyl
(5R,6S)-2-carbamoyloxymethyl-6-((1R)-hydroxyethyl)-2-penem-3-carboxylate
* FCE 22891
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JACHDX Journal of Antimicrobial Chemotherapy. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1975- Volume(issue)/page/year:
23(Suppl C),129,1989
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4363 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JACHDX Journal of Antimicrobial Chemotherapy. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1975- Volume(issue)/page/year:
23(Suppl C),129,1989
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 91 gm/kg/26W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - urine volume decreased
Kidney, Ureter, Bladder - other changes in urine composition
Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert
Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)-
1978- Volume(issue)/page/year: 23,34,1995
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 42 gm/kg/2W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
JACHDX Journal of Antimicrobial Chemotherapy. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1975- Volume(issue)/page/year:
23(Suppl C),129,1989
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 73 gm/kg/26W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert
Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)-
1978- Volume(issue)/page/year: 23,34,1995
*** END OF RECORD ***
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