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Benzamide,4-amino-N-(2,6-dimethylphenyl)-

MSDS	:	2',6'-Benzoxylidide, 4-amino-
CAS	:	787-93-9
SYNONYMS	:	* ADD 75073 * Ameltolide * 4-Amino-2',6'-benzoxylidide * 4-Amino-N-(2,6-dimethylphenyl)benzamide * Benzamide, 4-amino-N-(2,6-dimethylphenyl)- * LY201116

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[ 2',6'-Benzoxylidide, 4-amino- 787-93-9 ]

                     *** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : DM5325000
CHEMICAL NAME           : 2',6'-Benzoxylidide, 4-amino-
CAS REGISTRY NUMBER     : 787-93-9
BEILSTEIN REFERENCE NO. : 2734562
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C15-H16-N2-O
MOLECULAR WEIGHT        : 240.33
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * ADD 75073
   * Ameltolide
   * 4-Amino-2',6'-benzoxylidide
   * 4-Amino-N-(2,6-dimethylphenyl)benzamide
   * Benzamide, 4-amino-N-(2,6-dimethylphenyl)-
   * LY201116
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 161 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EPILAK Epilepsia (New York).  (Raven Press, 1185 Ave. of the Americas, New
   York, NY 10036) Ser.1-3: 1909-55; Ser.4: V.1-    1959-
   Volume(issue)/page/year: 29,198,1988
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 4095 mg/kg/13W-I
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Liver - changes in liver weight
   Related to Chronic Data - death
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   19,197,1992
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 600 mg/kg
SEX/DURATION            : female 6-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 44,37,1991
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 1300 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 44,37,1991
 
                            *** END OF RECORD ***

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