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4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2- carboxylic acid,3-[[(aminocarbonyl)oxy]- methyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-,(5R,6S)-

MSDS	:	4-Thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-(((aminocarbonyl)oxy)methyl)- 6-(1-hydroxyethyl)-7-oxo-, (5R-(5alpha,6alpha(R*)))-
CAS	:	84845-57-8
SYNONYMS	:	* Ritipenem

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[ 4-Thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylicacid, 3-(((aminocarbonyl)oxy)methyl)-6-(1-hydroxyethyl)-7-oxo-, (5R-(5alpha,6alpha(R*)))- 84845-57-8 ]

                     *** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XI0191750
CHEMICAL NAME           : 4-Thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic
                          acid, 3-(((aminocarbonyl)oxy)methyl)-
                          6-(1-hydroxyethyl)-7-oxo-, (5R-(5alpha,6alpha(R*)))-
CAS REGISTRY NUMBER     : 84845-57-8
LAST UPDATED            : 199606
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C10-H12-N2-O6-S
MOLECULAR WEIGHT        : 288.30
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Ritipenem
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
   Nutritional and Gross Metabolic - changes in potassium
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 29,3475,1995
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 3500 mg/kg/7D-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Kidney, Ureter, Bladder - other changes in urine composition
   Nutritional and Gross Metabolic - changes in chlorine
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 29,3475,1995
 
                            *** END OF RECORD ***

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