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Endothelin 3 (human)(9CI)

Conforms to 93/112/EC and ISO 11014-1

SAFETY DATA SHEET
Order Customer
Number
Number

Identification of the substance/preparation and of the company/undertaking
1.
Endothelin 3, Human and Rat : 05-23-3801
Product name : Catalog #
: Manufactured by EMD Biosciences, Inc.
Supplier
10394 Pacific Center Court
Chemical formula C121H168N26O33S4
:
San Diego, CA 92121
(858)450-5558/(800)854-3417
FAX: (858)453-3552

H-Cys1-Ser-Cys3-Ser-Ser-Trp-Leu-Asp-Lys-Glu-Cys11
:
Synonym
-Val-Tyr-Phe-Cys15-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide
bonds: 1 to 15; 3 to 11); ET-3

Emergency : Call Chemtrec?
telephone number (800)424-9300 (within U.S.A.)
(703)527-3887 (outside U.S.A.)

Composition / information on ingredients
2.
: Substance
Substance/Preparation

Chemical name* CAS No. EC Number Symbol R-Phrases
1) Endothelin 3, Human and Rat 117399-93-6 Not available. Xn R20/21/22

Hazards identification
3.
: Not applicable.
Physical/chemical hazards
: CAUTION!
Human health hazards
MAY BE HARMFUL IF INHALED, ABSORBED THROUGH SKIN OR SWALLOWED.
MAY CAUSE DAMAGE TO THE FOLLOWING ORGANS: BLOOD,
CARDIOVASCULAR SYSTEM, MUSCLE TISSUE.

First-aid measures
4.
First-Aid measures
: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Inhalation
Get medical attention.
: Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
Ingestion
unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen
tight clothing such as a collar, tie, belt or waistband.
: In case of contact, immediately flush skin with plenty of water. Remove contaminated clothing and shoes.
Skin Contact
Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention.
: Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at
Eye Contact
least 15 minutes. Get medical attention.

Effects and symptoms
Inhalation : Hazardous in case of inhalation.
: Hazardous in case of ingestion.
Ingestion
: Hazardous in case of skin contact (permeator).
Skin Contact
: Repeated or prolonged exposure is not known to aggravate medical condition.
Aggravating conditions

5. Fire-fighting measures
: Non-flammable.
Flammability of the Product
Extinguishing Media
: Not applicable.
Suitable
: Fire fighters should wear positive pressure self-contained breathing apparatus (SCBA) and full turnout gear.
Special fire-fighting procedures

05-23-3801
Catalog #
Accidental release measures
6.
: Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self-contained breathing apparatus should be
Personal precautions
used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a
specialist BEFORE handling this product.
: Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by
Small Spill and Leak
spreading water on the contaminated surface and dispose of according to local and regional authority
requirements.
: Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading
Large Spill and Leak
water on the contaminated surface and allow to evacuate through the sanitary system

Handling and storage
7.
: Do not ingest. Do not breathe dust. Avoid contact with skin. Wear suitable protective clothing. In case of
Handling
insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and
show the container or the label. Keep away from incompatibles such as acids, alkalis.
: Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above -20??C (-4??F).
Storage
Packaging materials
: Use original container.
Recommended use

Exposure controls/personal protection
8.
: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
Engineering measures
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure
to airborne contaminants below the exposure limit.
: Wash hands, forearms, and face thoroughly after handling compounds and before eating, smoking, using
Hygiene measures
lavatory, and at the end of day.
Ingredient Name Occupational Exposure Limits
1) Endothelin 3, Human and Rat Not available.

Personal protective equipment
: Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Respiratory system
: Lab coat.
Skin and body
: Gloves.
Hands
: Safety glasses.
Eyes
:
Protective Clothing
(Pictograms)

Physical and chemical properties
9.
: Solid. (Solid powder.)
Physical state
Color : White.
: 2643.1 g/mole
Molecular Weight
: Not available.
Solubility
Flash point : Not applicable.
: Risks of explosion of the product in presence of mechanical impact: Not available.
Explosive properties
Risks of explosion of the product in presence of static discharge: Not available.

10. Stability and reactivity
: The product is stable.
Stability
: Not available.
Conditions to avoid
: Reactive with acids, alkalis.
Materials to avoid

11. Toxicological information
:
RTECS # N/A
Local effects
Skin irritation : Not available.
: LD50: Not available.
Acute toxicity
LC50: Not available.

05-23-3801
Catalog #
: Repeated or prolonged exposure is not known to aggravate medical condition.
Chronic toxicity
: Not available.
Other Toxic Effects on
Humans Hazardous in case of skin contact (permeator), of ingestion, of inhalation.

Not available.

May be fatal, if the substance enters bloodstream. To the best of our knowledge, the toxicological
properties of this product have not been thoroughly investigated.

Carcinogenic effects : Not available.
: Not available.
Mutagenic effects
Reproduction toxicity : Not available.
: Not available.
Teratogenic effects

12. Ecological information
: Not available.
Ecotoxicity
: The products of degradation are less toxic than the product itself.
Toxicity of the Products of
Biodegradation

13. Disposal considerations
: Waste must be disposed of in accordance with federal, state and local environmental control regulations.
Methods of disposal; Waste of
residues; Contaminated packaging

14. Transport information
International transport regulations
Land - Road/Railway
: Not controlled under ADR (Europe).
ADR/RID Class
Sea
: Not controlled under IMDG.
IMDG Class
Air
: Not controlled under IATA.
IATA-DGR Class
Not applicable.
Special Provisions for
Transport

15. Regulatory information
EU Regulations
Hazard symbol(s) :

: Harmful
Classification
: R20/21/22- Harmful by inhalation, in contact with skin and if swallowed.
Risk Phrases
: S36- Wear suitable protective clothing.
Safety Phrases
: - Endothelin 3, Human and Rat
Contains
: TSCA: No products were found.
U.S. Federal Regulations
SARA 302/304/311/312 extremely hazardous substances: No products were found.
SARA 302/304 emergency planning and notification: No products were found.
SARA 302/304/311/312 hazardous chemicals: No products were found.
SARA 311/312 MSDS distribution - chemical inventory - hazard identification: No products were found.
SARA 313 toxic chemical notification and release reporting: No products were found.
Clean Water Act (CWA) 307: No products were found.
Clean Water Act (CWA) 311: No products were found.
Clean air act (CAA) 112 accidental release prevention: No products were found.
Clean air act (CAA) 112 regulated flammable substances: No products were found.
Clean air act (CAA) 112 regulated toxic substances: No products were found.
: CLASS: Target organ effects.
HCS Classification
:
State Regulations

: Not controlled under WHMIS (Canada).
WHMIS (Canada)
No products were found.

05-23-3801
Catalog #
16. Other information
Hazardous Material * 0 National Fire
Health
Fire Hazard
0
Information System 0 Protection
Fire Hazard
(U.S.A.) Association (U.S.A.) 0 0
Health Reactivity
0
Reactivity
Specific Hazard
E
Personal Protection

Notice to Reader
To the best of our knowledge, the information contained herein is accurate. However, neither the above named supplier nor any of its
subsidiaries assumes any liability whatsoever for the accuracy or completeness of the information contained herein.
Final determination of suitability of any material is the sole responsibility of the user. All materials may present unknown hazards and should be
used with caution. Although certain hazards are described herein, we cannot guarantee that these are the only hazards that exist.
Date of issue
3/12/2003.
05-23-3801
Catalog #

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