*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : VH4725000
CHEMICAL NAME : Restrictocin
CAS REGISTRY NUMBER : 1406-72-0
LAST UPDATED : 199606
DATA ITEMS CITED : 5
SYNONYMS/TRADE NAMES :
* NSC-53398
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 30 mg/kg
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from small intestine
Gastrointestinal - ulceration or bleeding from large intestine
REFERENCE :
NCINS* National Cancer Institute Report. (Bethesda, MD 20014)
Volume(issue)/page/year: -,9,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >400 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
Blood - hemorrhage
REFERENCE :
NCINS* National Cancer Institute Report. (Bethesda, MD 20014)
Volume(issue)/page/year: -,9,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 20 mg/kg
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from small intestine
Gastrointestinal - ulceration or bleeding from large intestine
REFERENCE :
NCINS* National Cancer Institute Report. (Bethesda, MD 20014)
Volume(issue)/page/year: -,9,1964
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 2240 ug/kg/28D-I
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Liver - other changes
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
REFERENCE :
NCINS* National Cancer Institute Report. (Bethesda, MD 20014)
Volume(issue)/page/year: -,9,1964
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 8960 ug/kg/28D-I
TOXIC EFFECTS :
Liver - fatty liver degeneration
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Blood - changes in leukocyte (WBC) count
REFERENCE :
NCINS* National Cancer Institute Report. (Bethesda, MD 20014)
Volume(issue)/page/year: -,9,1964
*** END OF RECORD ***
|