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5,8,11,14,16-Eicosapentaenoicacid, 18-hydroxy-, (5Z,8Z,11Z,14Z,16E)-

MSDS: (+/-)18-HEPE 3/21/02 1:20 PM

MATERIAL SAFETY DATA SHEET

SECTION 1. Chemical Product and Company Identification
(+/-)18-HEPE

Product Code: 32840 , Reference #: OHFA
Product Name: (+/-)18-HEPE
CAS Number: 141110-17-0
Chemical Family: Hydroxy Fatty Acids
Synonyms
(+/-)-18-hydroxy-5Z,8Z,11Z,14Z,16E-eicosapentaenoic acid
Manufacturer Name and Address: Telephone Numbers: Dates:
Cayman Chemical Company Cayman Chemical Company (800)364-9897 Date Entered: 10/05/2001
1180 E. Ellsworth Rd. Revision: 03/13/2002
Ann Arbor, MI. 48108 Cayman Chemical Company (734)971-3335 Printed: 03/14/2002

SECTION 2. Composition/Information on Ingredients
(+/-)18-HEPE

Hazardous Components (Specific Chemical Identity/Common Name) CAS # Percentage
(+/-)18-HEPE 141110-17-0 0.01
Ethyl alcohol 64-17-5 99.99

SECTION 3. Hazards Identification
(+/-)18-HEPE

Emergency Overview

Route(s) of Entry: Inhalation? Yes , Skin? Yes , Eyes? Yes , Ingestion? Yes , Other: Injection
Potential Health Effects (Acute and Chronic)
Contact may cause skin or eye irritation.
Material may be irritating to the mucous membranes and upper respiratory tract.
May be harmful by inhalation, ingestion, or skin absorption.
The toxicological properties of this compound have not been fully evaluated.
Carcinogeniticy: NTP? No , IARC Monographs? No , OSHA Regulated? No

file:///CAYMAN.SYS/SHARE/PDFs/MSDSs/32840m.htm MSDS: (+/-)18-HEPE 3/21/02 1:20 PM

Carcinogenicity/Other Information

Signs and Symptoms Of Exposure
Irritating to the skin, eyes, nose, throat, and respiratory tract.

SECTION 4. First Aid Measures
(+/-)18-HEPE

Emergency and First Aid Procedures
If inhaled remove to fresh air. If not breathing, give artificial respiration or give oxygen by trained personnel. Get immediate
medical attention.
If swallowed, wash out mouth with water provided person is conscious. Never give anything by mouth to an unconscious
person. Get medical attention.
In case of contact with eyes, hold eyelids apart and flush eyes with plenty of water. After initial flushings, remove any contact
lenses and continue flushing for at least 15 minutes. Have eyes examined and tested by medical personnel.
In case of skin contact, immediately wash skin with soap and plenty of water. Remove contaminated clothing. Get medical
attention if symptoms occur. Wash clothing before reuse.
Note to Physician

Medical Conditions Generally Aggravated By Exposure

SECTION 5. Fire Fighting Measures
(+/-)18-HEPE

Flash Pt: NE or NA Method Used:
Explosive Limits: LEL: UEL:
Autoignition Pt: NE or NA Extinguishing Media
Use alcohol foam, carbon dioxide, or water spray when fighting fires involving this material.
Fire Fighting Instructions
As in any fire, wear self-contained breathing apparatus pressure-demand (MSHA/NIOSH approved or equivalent), and full
protective gear to prevent contact with skin and eyes.
Note: Flammable as diluted in ethanol.
Flammable Properties and Hazards
Container explosion may occur under fire conditions.
Emits toxic fumes under fire conditions.
Flammable liquid.
Can release vapors that form explosive mixtures at temperatures at or above the flashpoint.
Vapors can travel to a source of ignition and flash back.
Hazardous Combustion Products
carbon dioxide
carbon monoxide

SECTION 6. Accidental Release Measures
(+/-)18-HEPE

Steps To Be Taken In Case Material Is Released Or Spilled

file:///CAYMAN.SYS/SHARE/PDFs/MSDSs/32840m.htm MSDS: (+/-)18-HEPE 3/21/02 1:20 PM

Absorb spill with inert material (e.g. dry sand or earth), then place in a chemical waste container.
After removal, flush the contaminated area thoroughly with water.

SECTION 7. Handling and Storage
(+/-)18-HEPE

Hazard Label Information:
Avoid contact with skin and eyes. Use with adequate ventilation.
Do not reuse this container. Wash thoroughly after handling.
Precautions To Be Taken in Handling
Avoid contact with eyes, skin, and clothing.
Do not reuse this container.
Keep away from sources of ignition.
Use with adequate ventilation.
Wash thoroughly after handling.
Precautions To Be Taken in Storing
Store at correct temperature.
Other Precautions

Work/Hygienic/Maintenance Practices
Do not take internally.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Wash thoroughly after handling.

SECTION 8. Exposure Controls/Personal Protection
(+/-)18-HEPE

Protective Equipment Summary - Hazard Label Information
Eye wash station in work area Latex disposable gloves Safety shower in work area
Lab coat Safety glasses Vent Hood
Respiratory Equipment (Specify Type)

Eye Protection
Safety glasses
Protective Gloves
Latex disposable gloves
Other Protective Clothing
Lab coat
Engineering Controls (Ventilation etc.)
Good general ventilation should be sufficient to control airborne levels.

SECTION 9. Physical and Chemical Properties
(+/-)18-HEPE

file:///CAYMAN.SYS/SHARE/PDFs/MSDSs/32840m.htm MSDS: (+/-)18-HEPE 3/21/02 1:20 PM

Physical States: [ ] Gas , [ X ] Liquid , [ ] Solid
Boiling Point: NE or NA
Melting Point:
Specific Gravity (Water = 1): NE or NA
Vapor Pressure (vs. Air or mm Hg): NE or NA
Vapor Density (vs. Air = 1): NE or NA
Evaporation Rate (vs Butyl Acetate=1): NE or NA
Solubility in Water: 0.8 mg/ml* at 25.0 C
Other Solubility Notes: *PBS (pH 7.2), sol. in DMSO and DMF
Percent Volatile: NE or NA
Molecular Formula: C20H30O3
Molecular Weight: 318.50
pH:
Appearance and Odor
A clear, colorless solution

SECTION 10. Stability and Reactivity
(+/-)18-HEPE

Stability: Unstable [ ] Stable [ X ]
Conditions To Avoid - Instability

Incompatibility - Materials To Avoid

Hazardous Decomposition Or Byproducts
carbon dioxide
carbon monoxide
Hazardous Polymerization: Will occur [ ] Will not occur [ X ]
Conditions To Avoid - Hazardous Polymerization

SECTION 11. Toxicological Information
(+/-)18-HEPE

The toxicological effects of this compound have not been thoroughly studied.
Chronic Toxicological Effects

SECTION 12. Ecological Information
(+/-)18-HEPE

Data not yet available.

SECTION 13. Disposal Considerations
(+/-)18-HEPE

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Waste Disposal Method
Dispose in accordance with local, state and federal regulations.

SECTION 14. Transport Information
(+/-)18-HEPE

DOT Proper Shipping Name

Additional Transport Information
Transport in accordance with local, state, and federal regulations.

SECTION 15. Regulatory Information
(+/-)18-HEPE

The data given here is based on current knowledge and experience. The purpose of this safety data sheet is to describe the
products in terms of their safety requirements. The data does not signify any guarantee with regard to the product's
properties.

SECTION 16. Other Information
(+/-)18-HEPE

For research use only, not for human or veterinary clinical use.
DISCLAIMER: This information is believed to be accurate and represents the best information currently available to us.
However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information,
and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of
the information for their particular purposes.

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