*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : TK6060000
CHEMICAL NAME : 2',6'-Pipecoloxylidide, 1-butyl-
CAS REGISTRY NUMBER : 2180-92-9
LAST UPDATED : 199612
DATA ITEMS CITED : 11
MOLECULAR FORMULA : C18-H28-N2-O
MOLECULAR WEIGHT : 288.48
WISWESSER LINE NOTATION : T6NTJ A4 BVMR B1 F1
COMPOUND DESCRIPTOR : Drug
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Bupivacaine
* DL-Bupivacaine
* 1-Butyl-2',6'-pipecoloxylidide
* Carbostesin
* Marcaine
* 2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylphenyl)-
* WIN 11318
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Human
DOSE/DURATION : 4300 ug/kg
TOXIC EFFECTS :
Vascular - measurement of regional blood flow
Behavioral - euphoria
REFERENCE :
AANEAB Acta Anaesthesiologica Scandinavica. (Munksgaard International Pub.,
POB 2148, DK-1016 Copenhagen K, Denmark) V.1- 1957-
Volume(issue)/page/year: 21,521,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 47 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9,
Washington, DC 20231) Volume(issue)/page/year: #3632766
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
31,273,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 35 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9,
Washington, DC 20231) Volume(issue)/page/year: #3632766
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 7100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9,
Washington, DC 20231) Volume(issue)/page/year: #3632766
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1620 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co.,
Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957-
Volume(issue)/page/year: 64,209,1985
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 64 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 26,78,1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intratracheal
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 12500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 26,78,1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 36600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9,
Washington, DC 20231) Volume(issue)/page/year: #3632766
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intracervical
SPECIES OBSERVED : Human - woman
DOSE : 500 ug/kg
SEX/DURATION : female 39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular
(circulatory) system
REFERENCE :
JPEMAO Journal of Perinatal Medicine. (Walter de Gruyter, Inc., 200 Saw
Mill River Rd., Hawthorne, NY 10532) V.1- 1973- Volume(issue)/page/year:
12,75,1984
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraspinal
SPECIES OBSERVED : Human - woman
DOSE : 2396 mg/kg
SEX/DURATION : female 39 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
BJOGAS British Journal of Obstetrics and Gynaecology. (Blackwell Scientific
Pub. Ltd., POB 88, Oxford, UK) V.82- 1975- Volume(issue)/page/year:
88,407,1981
*** END OF RECORD ***
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