*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : XO8576500
CHEMICAL NAME : Threitol, 1,4-dithio-, DL-
CAS REGISTRY NUMBER : 27565-41-9
BEILSTEIN REFERENCE NO. : 1719757
REFERENCE : 3-01-00-02360 (Beilstein Handbook Reference)
LAST UPDATED : 199806
DATA ITEMS CITED : 8
MOLECULAR FORMULA : C4-H10-O2-S2
MOLECULAR WEIGHT : 154.26
WISWESSER LINE NOTATION : SH1YQYQ1SH -DL, THREO
COMPOUND DESCRIPTOR : Mutagen
SYNONYMS/TRADE NAMES :
* 2,3-Butanediol, 1,4-dimercapto-, DL-threo-
* 2,3-Butanediol, 1,4-dimercapto-, (R*,R*)- (+-)-
* Cleland's reagent
* DL-threo-1,4-Dimercapto-2,3-butanediol
* (R*,R*)-(+-)-1,4-Dimercapto-2,3-butanediol
* Dithiothreitol
* DL-Dithiothreitol
* DL-1,4-Dithiothreitol
* rac-Dithiothreitol
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 169 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
20037) V.6- 1963- Volume(issue)/page/year: 15,600,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 333 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 22,1434,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 94 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 22,1434,1972
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 100 ug/plate
REFERENCE :
ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050,
Tokyo International, Tokyo 100-31, Japan) V.25- 1961-
Volume(issue)/page/year: 45,327,1981
TYPE OF TEST : DNA damage
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 1 mmol/L
REFERENCE :
BBRCA9 Biochemical and Biophysical Research Communications. (Academic
Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
Volume(issue)/page/year: 77,1150,1977
TYPE OF TEST : Micronucleus test
TEST SYSTEM : Non-mammalian species Embryo
DOSE/DURATION : 2 mmol/L
REFERENCE :
JCLBA3 Journal of Cell Biology. (Rockefeller Univ. Press, 1230 York Ave.,
New York, NY 10003) V.12- 1962- Volume(issue)/page/year: 60,497,1974
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 1 mmol/L
REFERENCE :
ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year:
166,400,1975
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X2950
No. of Facilities: 35 (estimated)
No. of Industries: 1
No. of Occupations: 3
No. of Employees: 627 (estimated)
No. of Female Employees: 436 (estimated)
*** END OF RECORD ***
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