*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : EI2996700
CHEMICAL NAME : 5-beta-Bufa-20,22-dienolide, 3-beta,5,14-trihydroxy-
CAS REGISTRY NUMBER : 472-26-4
BEILSTEIN REFERENCE NO. : 0056287
REFERENCE : 4-18-00-02553 (Beilstein Handbook Reference)
LAST UPDATED : 199709
DATA ITEMS CITED : 4
MOLECULAR FORMULA : C24-H34-O5
MOLECULAR WEIGHT : 402.58
WISWESSER LINE NOTATION : L E5 B666TJ A1 E1 IQ MQ OQ F- ET6OVJ
COMPOUND DESCRIPTOR : Drug
Natural Product
SYNONYMS/TRADE NAMES :
* Telocinobufagin
* Telocinobufogenin
* 3-beta,5,14-Trihydroxy-5-beta-bufa-20,22-dienolide
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4340 ug/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Behavioral - antipsychotic
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA,
1255 Howard St., San Francisco, CA 94103) V.6- 1958-
Volume(issue)/page/year: 24,1714,1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 102 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHUZBI Pharmazie in Unserer Zeit. (VCH Pub., Inc., 303 N.W. 12th Ave.,
Deerfield Beach, FL 33441) V.1- 1972- Volume(issue)/page/year:
13,129,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster,
Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year:
-,194,1963
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 1102 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHUZBI Pharmazie in Unserer Zeit. (VCH Pub., Inc., 303 N.W. 12th Ave.,
Deerfield Beach, FL 33441) V.1- 1972- Volume(issue)/page/year:
13,129,1984
*** END OF RECORD ***
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