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[1,1'-Biphenyl]-4-acetic acid, 2-fluoro-a-methyl-, (±)-

MSDS: (+/-)-Flurbiprofen 2/27/02 3:48 PM

MATERIAL SAFETY DATA SHEET

This form complies with OSHA's Hazard Communication Standard, 29 CFR 1910.1200.
IDENTITY (As Used on Label and List): (+/-)-Flurbiprofen

SECTION I - Product Identification
(+/-)-Flurbiprofen

Manufacturer Name and Address: Telephone Numbers:
Cayman Chemical Company Cayman Chemical (800)364-9897
1180 E. Ellsworth Rd.
Ann Arbor, MI. 48108 Cayman Chemical (734)971-3335

Date Entered: 10/17/97 Last Revision: 07/02/98 MSDS Printed: 10/01/99

Synonyms:
Ansaid; [1,1'Biphenyl]-4-acetic acid, 2-fluoro-??-methyl-, (+/-)-

Chemical Family: Inhibitors
Hazard Label:
Molecular Formula: C15H13FO2 Molecular Weight: 244.30

NFPA Ratings: (0-4) NFPA Specific Hazards
Health: 2
Flammability: 0
Reactivity: 0

SECTION II - Hazardous Ingredients/Identity Information
(+/-)-Flurbiprofen

Hazardous Components (Specific Chemical Identity/Common Name) CAS #
(+/-)-Flurbiprofen {Ansaid} 51543-38-5

CAS # OSHA PEL ACGIH TLV Other Limits Percentage
51543-38-5 100.0

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SECTION III - Physical/Chemical Characteristics
(+/-)-Flurbiprofen

Boiling Point: . . . NE or NA
Melting Point: . . . 113.0C to: 114.0C
Specific Gravity: . . . NE or NA (Water = 1)
Vapor Pressure: . . . NE or NA (mm Hg)
Vapor Density: . . . NE or NA (Air = 1)
Physical States: . . . [ ] Gas , [ ] Liquid , [ X ] Solid
Evaporation Rate: . . . NE or NA (Butyl Acetate = 1)
Solubility In Water: . . .
Percent Volatile: . . . NE or NA

Appearance and Odor:
A crystalline solid.

SECTION IV - Fire and Explosion Hazard Data
(+/-)-Flurbiprofen

Flash Pt: NE or NA Method Used:
Explosive Limits: LEL: UEL: Autoignition Pt: NE or NA

Extinguishing Media:
Use alcohol foam, carbon dioxide, or water spray when fighting fires involving this material.

Special Fire Fighting Procedures:

Unusual Fire and Explosion Hazards:
Combustion generates toxic fumes of carbon monoxide and carbon dioxide.

SECTION V - Reactivity Data
(+/-)-Flurbiprofen

Stability: Unstable [ ] Stable [ X ]

Conditions To Avoid - Instability:

Incompatibility - Materials To Avoid:

Hazardous Decomposition Or Byproducts:
carbon dioxide, carbon monoxide

Hazardous Polymerization: May occur [ ] Will not occur [ X ]

Conditions To Avoid - Hazardous Polymerization:

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SECTION VI - Health Hazard Data
(+/-)-Flurbiprofen

Route(s) of Entry: Inhalation? Yes , Skin? Yes , Eyes? Yes , Ingestion? Yes
Other:

Health Hazards (Acute and Chronic):
May be fatal if swallowed, inhaled, or absorbed through the skin. Contact may cause skin or eye irritation. May cause
gastrointestinal disturbances, dermatological effects, renal problems, CNS disturbances, hematological disturbances,
respiratory problems, cardiovascular disturbances, thrombocytopenia, neutropenia.

Carcinogenicity: NTP? No , IARC Monographs? , OSHA Regulated?

Carcinogenicity/Other Information:

Recommended Exposure Limits:
LD 50/LC 50: Oral (dog) LD50 = 10 mg/kg

Signs and Symptoms Of Exposure:
Irritating to the nose, throat and respiratory tract.

Medical Conditions Generally Aggravated By Exposure:

Emergency and First Aid Procedures:
If swallowed, wash out mouth with water provided person is conscious. Never give anything by mouth to an unconscious
person. Get medical attention. In case of skin contact, immediately wash skin with soap and plenty of water. Remove
contaminated clothing. Get medical attention if symptoms occur. Wash clothing before reuse. Remove to fresh air. If not
breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. In case of contact with eyes,
hold eyelids apart and flush eyes with plenty of water. After initial flushings, remove any contact lenses and continue
flushing for at least 15 minutes. Have eyes examined and tested by medical personnel.

SECTION VII - Precautions for Safe Handling and Use
(+/-)-Flurbiprofen

Steps To Be Taken In Case Material Is Released Or Spilled:
Vacuum or sweep up material and place in disposal container. After removal, flush contaminated area thoroughly with
water.

Waste Disposal Method:
Dispose in accordance with local, state and federal regulations.

Hazard Label Information: Avoid contact with skin and eyes. Do not reuse this container. Use with adequate ventilation.
Wash thoroughly after handling.

Precautions To Be Taken in Handling and Storing:
Avoid contact with eyes, skin, and clothing. Avoid breathing (dust, vapor, mist, gas). Do not reuse this container. Provide
adequate ventilation. Wash thoroughly after handling.

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Other Precautions:

SECTION VIII- Control Measures
(+/-)-Flurbiprofen

Protective Equipment Summary - Hazard Label Information Safety glasses Latex disposable gloves Safety shower in work
area Eye wash station in work area Vent Hood

Respiratory Equipment (Specify Type):

Ventilation:
Good general ventilation should be sufficient to control airborne levels.

Eye Protection:
Safety glasses

Protective Gloves:
Latex disposable gloves

Other Protective Clothing:

Work/Hygienic/Maintenance Practices:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Wash
thoroughly after handling.

SECTION IX - Additional Comments
(+/-)-Flurbiprofen

For research use only, not for human or veterinary clinical use.

For research use only, not for human or veterinary clinical use. DISCLAIMER:
This information is believed to be accurate and represents the best information currently available to us. However, we
make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we
assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the
information for their particular purposes.

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