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3-Hydroxytyramine hydrochloride

1.1

IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

Product identifiers

Product name

Product Number

Brand

CAS-No.

Dopamine hydrochloride

H8502

Anonymous

62-31-7

1.2

Relevant identified uses of the substance or mixture and uses advised against

Identified uses

Laboratory chemicals, Manufacture of substances

2.1

2.2

HAZARDS IDENTIFICATION

Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]

Acute toxicity, Oral (Category 4)

Acute aquatic toxicity (Category 1)

Chronic aquatic toxicity (Category 1)

Classification according to EU Directives 67/548/EEC or 1999/45/EC

Harmful if swallowed. Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic

environment.

Label elements

Labelling according Regulation (EC) No 1272/2008 [CLP]

Pictogram

Signal word

Hazard statement(s)

H302

H410

Precautionary statement(s)

P273

P501

Supplemental Hazard

Statements

Warning

Harmful if swallowed.

Very toxic to aquatic life with long lasting effects.

Avoid release to the environment.

Dispose of contents/ container to an approved waste disposal plant.

none

According to European Directive 67/548/EEC as amended.

Hazard symbol(s)

R-phrase(s)

R22

R50/53

Harmful if swallowed.

Very toxic to aquatic organisms, may cause long-term adverse effects in

the aquatic environment.

S-phrase(s)

S61

Avoid release to the environment. Refer to special instructions/ Safety

data sheets.

2.3

3.1

Other hazards - none

COMPOSITION/INFORMATION ON INGREDIENTS

Substances

Synonyms

Formula

Molecular Weight

Component

Dopamine hydrochloride

3,4-Dihydroxyphenethylaminehydrochloride

4-(2-Aminoethyl)-1,2-benzenediolhydrochloride

2-(3,4-Dihydroxyphenyl)ethylaminehydrochloride

3-Hydroxytyramine hydrochloride

C8H11NO2 · HCl

189,64 g/mol

Concentration

CAS-No.

EC-No.

62-31-7

200-527-8

4.1

4.2

4.3

5.1

FIRST AID MEASURES

Description of first aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Flush eyes with water as a precaution.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Most important symptoms and effects, both acute and delayed

Nausea, Headache, Vomiting, To the best of our knowledge, the chemical, physical, and toxicological

properties have not been thoroughly investigated.

Indication of any immediate medical attention and special treatment needed

no data available

FIREFIGHTING MEASURES

Extinguishing media

Suitable extinguishing media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2

5.3

5.4

6.1

6.2

6.3

6.4

7.1

7.2

7.3

8.1

8.2

Special hazards arising from the substance or mixture

Carbon oxides, nitrogen oxides (NOx), Hydrogen chloride gas

Advice for firefighters

Wear self contained breathing apparatus for fire fighting if necessary.

Further information

no data available

ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure

adequate ventilation. Avoid breathing dust.

Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the

environment must be avoided.

Methods and materials for containment and cleaning up

Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed

containers for disposal.

Reference to other sections

For disposal see section 13.

HANDLING AND STORAGE

Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols.

Provide appropriate exhaust ventilation at places where dust is formed.

Conditions for safe storage, including any incompatibilities

Protect against light. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

Recommended storage temperature: 2 - 8 °C

Keep in a dry place.

Specific end uses

no data available

EXPOSURE CONTROLS/PERSONAL PROTECTION

Control parameters

Components with workplace control parameters

Exposure controls

Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and

at the end of workday.

Personal protective equipment

Eye/face protection

Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested

and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique

(without touching glove's outer surface) to avoid skin contact with this product. Dispose of

contaminated gloves after use in accordance with applicable laws and good laboratory practices.

Wash and dry hands.

The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and

the standard EN 374 derived from it.

Immersion protection

Material: Nitrile rubber

Minimum layer thickness: 0,11 mm

Break through time: > 480 min

Material tested:Dermatril? (Anonymous Z677272, Size M)

Splash protection

Material: Nitrile rubber

Minimum layer thickness: 0,11 mm

Break through time: > 30 min

Material tested:Dermatril? (Anonymous Z677272, Size M)

data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 873000, e-mail sales@kcl.de,

test method: EN374

If used in solution, or mixed with other substances, and under conditions which differ from EN 374,

contact the supplier of the CE approved gloves. This recommendation is advisory only and must

be evaluated by an Industrial Hygienist familiar with the specific situation of anticipated use by our

customers. It should not be construed as offering an approval for any specific use scenario.

Body Protection

Complete suit protecting against chemicals, The type of protective equipment must be selected

according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection

For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher

level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges.

Use respirators and components tested and approved under appropriate government standards

such as NIOSH (US) or CEN (EU).

9.1

PHYSICAL AND CHEMICAL PROPERTIES

Information on basic physical and chemical properties

Appearance

Odour

Odour Threshold

Melting point/freezing

point

Initial boiling point and

boiling range

Flash point

Evaporation rate

Form: powder

Colour: white

no data available

3,0 - 5,5 at 40,0 g/l at 20 °C

Melting point/range: 248 - 250 °C

no data available

Flammability (solid, gas) no data available

Upper/lower

flammability or

explosive limits

Vapour pressure

Vapour density

no data available

m) Relative density

no data available

Water solubility

Partition coefficient: n-

octanol/water

Autoignition

temperature

Decomposition

no data available

log Pow: -2,58 at 25 °C

no data available

temperature

Viscosity

Explosive properties

Oxidizing properties

no data available

9.2

10.

10.1

10.2

10.3

10.4

10.5

10.6

11.

11.1

Other safety information

no data available

STABILITY AND REACTIVITY

Reactivity

no data available

Chemical stability

no data available

Possibility of hazardous reactions

no data available

Conditions to avoid

Light.

Incompatible materials

Strong oxidizing agents

Hazardous decomposition products

Other decomposition products - no data available

TOXICOLOGICAL INFORMATION

Information on toxicological effects

Acute toxicity

LD50 Oral - rat - 1.870 mg/kg

LC50 Inhalation - rat - 4 h - > 5,0 mg/l

LD50 Intravenous - rat - 4,8 mg/kg

Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and Taste):Olfaction:Other changes.

Behavioral:Convulsions or effect on seizure threshold. Lungs, Thorax, or Respiration:Dyspnea.

Skin corrosion/irritation

Skin - rabbit - No skin irritation - OECD Test Guideline 404

Serious eye damage/eye irritation

Eyes - rabbit - No eye irritation - OECD Test Guideline 405

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

IARC:

No component of this product present at levels greater than or equal to 0.1% is identified as

probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity

no data available

Specific target organ toxicity - single exposure

no data available

Specific target organ toxicity - repeated exposure

no data available

Aspiration hazard

no data available

Potential health effects

Inhalation

Ingestion

Skin

Eyes

May be harmful if inhaled. May cause respiratory tract irritation.

Harmful if swallowed.

May be harmful if absorbed through skin. May cause skin irritation.

May cause eye irritation.

Signs and Symptoms of Exposure

Nausea, Headache, Vomiting, To the best of our knowledge, the chemical, physical, and toxicological

properties have not been thoroughly investigated.

Additional Information

RTECS: UX1092000

12.

12.1

ECOLOGICAL INFORMATION

Toxicity

Toxicity to fish

Toxicity to daphnia and

other aquatic

invertebrates

Toxicity to algae

static test LC50 - Leuciscus idus (Golden orfe) - 2.200,0 - 4.600,0 mg/l - 96,0 h

Method: DIN 38412

static test EC50 - Daphnia magna (Water flea) - 24,5 mg/l - 48 h

Method: OECD Test Guideline 202

static test EC50 - Algae - < 1 mg/l - 72 h

Method: OECD Test Guideline 201

12.2

Persistence and degradability

Biodegradability

Biotic/Aerobic

Result: 60 - 70 % - According to the results of tests of biodegradability this

product is not readily biodegradable.

Method: Directive 67/548/EEC Annex V, C.4.C.

12.3

12.4

12.5

12.6

13.

13.1

14.

14.1

Bioaccumulative potential

Bioaccumulation is unlikely.

Mobility in soil

no data available

Results of PBT and vPvB assessment

no data available

Other adverse effects

Very toxic to aquatic life with long lasting effects.

DISPOSAL CONSIDERATIONS

Waste treatment methods

Product

Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material

with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.

Contaminated packaging

Dispose of as unused product.

TRANSPORT INFORMATION

UN number

14.2

ADR/RID: 3077

UN proper shipping name

IMDG: 3077

IATA: 3077

ADR/RID:

IMDG:

IATA:

ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (Dopamine

hydrochloride)

ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (Dopamine

hydrochloride)

Environmentally hazardous substance, solid, n.o.s. (Dopamine hydrochloride)

14.3

Transport hazard class(es)

14.4

14.5

14.6

15.

ADR/RID: 9

Packaging group

ADR/RID: III

Environmental hazards

ADR/RID: yes

Special precautions for user

no data available

REGULATORY INFORMATION

IMDG: 9

IMDG: III

IMDG Marine pollutant: yes

IATA: 9

IATA: III

IATA: yes

This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.1

15.2

16.

Safety, health and environmental regulations/legislation specific for the substance or mixture

no data available

Chemical Safety Assessment

no data available

OTHER INFORMATION

Further information

The above information is believed to be correct but does not purport to be all inclusive and
shall be used only as a guide. The informationin this document is based on the resent state
of our knowledge and is applicable to the product with regard toappropriate safety precautions.
It does not represent any guarantee of the properties of the product. Lookchem shall not be
held liable for any damage resulting from handling or from contact with the above product.
See reverse side of invoice or packing slip for additional terms and conditions of sale.

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