Carboxypeptidase A

1. 1.1 IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING Product identifiers Product name Product Number Brand CAS-No. : : : : Carboxypeptidase A, from bovine pancreas C9268 Anonymous 11075-17-5 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Manufacture of substances 2. 2.1 2.2 HAZARDS IDENTIFICATION Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP] Flammable liquids (Category 2) Skin irritation (Category 2) Respiratory sensitization (Category 1) Reproductive toxicity (Category 2) Specific target organ toxicity - repeated exposure (Category 2) Aspiration hazard (Category 1) Classification according to EU Directives 67/548/EEC or 1999/45/EC Highly flammable. Harmful: may cause lung damage if swallowed. Harmful: danger of serious damage to health by prolonged exposure through inhalation. Possible risk of harm to the unborn child. May cause sensitization by inhalation. Label elements Labelling according Regulation (EC) No 1272/2008 [CLP] Pictogram Signal word Hazard statement(s) H225 H304 H315 H334 H361d Danger Highly flammable liquid and vapour. May be fatal if swallowed and enters airways. Causes skin irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled. Suspected of damaging the unborn child. H373 Precautionary statement(s) P210 P261 P281 P301 + P310 P331 P342 + P311 Supplemental Hazard May cause damage to organs through prolonged or repeated exposure. Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. Use personal protective equipment as required. IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. Do NOT induce vomiting. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/ physician. none Statements According to European Directive 67/548/EEC as amended. Hazard symbol(s) R-phrase(s) R11 R42 R48/20 R63 R65 S-phrase(s) S16 S23 S36/37 S45 S62 Highly flammable. May cause sensitization by inhalation. Harmful: danger of serious damage to health by prolonged exposure through inhalation. Possible risk of harm to the unborn child. Harmful: may cause lung damage if swallowed. Keep away from sources of ignition - No smoking. Do not breathe vapour. Wear suitable protective clothing and gloves. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label. 2.3 3. 3.2 Other hazards - none COMPOSITION/INFORMATION ON INGREDIENTS Mixtures Synonyms : Carboxypolypeptidase Peptidyl-L-amino-acid hydrolase Component Toluene Classification Concentration CAS-No. EC-No. Index-No. 108-88-3 203-625-9 601-021-00-3 Flam. Liq. 2; Repr. 2; Asp. Tox. 1; STOT RE 2; Skin Irrit. 2; STOT SE 3; H225, H304, 10 - 15 % H315, H336, H361d, H373 F, Xn, Repr.Cat.3, R11 - R38 - R48/20 - R63 - R65 - R67 Carboxypeptidase A CAS-No. EC-No. Index-No. 11075-17-5 234-297-5 647-014-00-9 Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Resp. Sens. 1; H319, H315, H334, H335 1 - 10 % Xn, R36/37/38 - R42 For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16 4. 4.1 4.2 4.3 5. 5.1 5.2 5.3 5.4 6. 6.1 6.2 6.3 6.4 7. 7.1 FIRST AID MEASURES Description of first aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. Most important symptoms and effects, both acute and delayed Lung irritation, chest pain, pulmonary edema, Inhalation studies on toluene have demonstrated the development of inflammatory and ulcerous lesions of the penis, prepuce, and scrotum in animals. Indication of any immediate medical attention and special treatment needed no data available FIREFIGHTING MEASURES Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special hazards arising from the substance or mixture Carbon oxides Advice for firefighters Wear self contained breathing apparatus for fire fighting if necessary. Further information Use water spray to cool unopened containers. ACCIDENTAL RELEASE MEASURES Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas. Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13). Reference to other sections For disposal see section 13. HANDLING AND STORAGE Precautions for safe handling Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge. 7.2 7.3 8. 8.1 8.2 9. 9.1 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Recommended storage temperature: 2 - 8 °C Specific end uses no data available EXPOSURE CONTROLS/PERSONAL PROTECTION Control parameters Components with workplace control parameters Exposure controls Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Personal protective equipment Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Body Protection Complete suit protecting against chemicals, Flame retardant antistatic protective clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). PHYSICAL AND CHEMICAL PROPERTIES Information on basic physical and chemical properties a) b) c) d) e) f) g) h) Appearance Odour Odour Threshold pH Melting point/freezing point Initial boiling point and boiling range Flash point Evaporation rate Form: suspension no data available no data available no data available no data available no data available 4 °C no data available i) Flammability (solid, gas) no data available j) k) l) Upper/lower flammability or explosive limits Vapour pressure Vapour density no data available no data available no data available m) Relative density 1,000 g/cm3 n) o) p) q) r) s) t) Water solubility Partition coefficient: n- octanol/water Autoignition temperature Decomposition temperature Viscosity Explosive properties Oxidizing properties no data available no data available no data available no data available no data available no data available no data available 9.2 10. 10.1 10.2 10.3 10.4 10.5 10.6 11. 11.1 Other safety information no data available STABILITY AND REACTIVITY Reactivity no data available Chemical stability no data available Possibility of hazardous reactions no data available Conditions to avoid Heat, flames and sparks. Extremes of temperature and direct sunlight. Incompatible materials Oxidizing agents, Strong oxidizing agents Hazardous decomposition products Other decomposition products - no data available TOXICOLOGICAL INFORMATION Information on toxicological effects Acute toxicity no data available Skin corrosion/irritation no data available Serious eye damage/eye irritation no data available Respiratory or skin sensitization no data available Germ cell mutagenicity no data available Carcinogenicity IARC: 3 - Group 3: Not classifiable as to its carcinogenicity to humans (Toluene) Reproductive toxicity no data available Specific target organ toxicity - single exposure no data available Specific target organ toxicity - repeated exposure no data available Aspiration hazard no data available Potential health effects Inhalation Ingestion Skin Eyes Harmful if inhaled. Causes respiratory tract irritation. Harmful if swallowed. Aspiration hazard if swallowed - can enter lungs and cause damage. Harmful if absorbed through skin. Causes skin irritation. Causes serious eye irritation. Signs and Symptoms of Exposure Lung irritation, chest pain, pulmonary edema, Inhalation studies on toluene have demonstrated the development of inflammatory and ulcerous lesions of the penis, prepuce, and scrotum in animals. Additional Information RTECS: Not available 12. 12.1 12.2 12.3 12.4 12.5 12.6 13. 13.1 14. 14.1 ECOLOGICAL INFORMATION Toxicity no data available Persistence and degradability no data available Bioaccumulative potential no data available Mobility in soil no data available Results of PBT and vPvB assessment no data available Other adverse effects Harmful to aquatic life. DISPOSAL CONSIDERATIONS Waste treatment methods Product Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contaminated packaging Dispose of as unused product. TRANSPORT INFORMATION UN number 14.2 ADR/RID: 1294 UN proper shipping name IMDG: 1294 IATA: 1294 ADR/RID: IMDG: IATA: TOLUENE, SOLUTION TOLUENE, SOLUTION Toluene, SOLUTION 14.3 Transport hazard class(es) 14.4 14.5 14.6 15. ADR/RID: 3 Packaging group ADR/RID: II Environmental hazards ADR/RID: no Special precautions for user no data available REGULATORY INFORMATION IMDG: 3 IMDG: II IMDG Marine pollutant: no IATA: 3 IATA: II IATA: no This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006. 15.1 15.2 16. Safety, health and environmental regulations/legislation specific for the substance or mixture no data available Chemical Safety Assessment no data available OTHER INFORMATION Text of H-code(s) and R-phrase(s) mentioned in Section 3 Asp. Tox. Eye Irrit. Flam. Liq. H225 H304 H315 H319 H334 H335 H336 H361d H373 Repr. Resp. Sens. Skin Irrit. STOT RE STOT SE F R11 R36/37/38 R38 Xn R42 R48/20 R63 R65 R67 Repr.Cat.3 Aspiration hazard Eye irritation Flammable liquids Highly flammable liquid and vapour. May be fatal if swallowed and enters airways. Causes skin irritation. Causes serious eye irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause respiratory irritation. May cause drowsiness or dizziness. Suspected of damaging the unborn child. May cause damage to organs through prolonged or repeated exposure. Reproductive toxicity Respiratory sensitization Skin irritation Specific target organ toxicity - repeated exposure Specific target organ toxicity - single exposure Highly flammable Highly flammable. Irritating to eyes, respiratory system and skin. Irritating to skin. Harmful May cause sensitization by inhalation. Harmful: danger of serious damage to health by prolonged exposure through inhalation. Possible risk of harm to the unborn child. Harmful: may cause lung damage if swallowed. Vapours may cause drowsiness and dizziness. Toxic to Reproduction Category 3 Further information The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information this document is based on the resent state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Lookchem shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale.

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