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Benzene-1,2,3,4,5,6-d6

1.1

IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

Product identifiers

Product name

Product Number

Brand

CAS-No.

Benzene-d6

236977

Anonymous

1076-43-3

1.2

Relevant identified uses of the substance or mixture and uses advised against

Identified uses

Laboratory chemicals, Manufacture of substances

2.1

2.2

HAZARDS IDENTIFICATION

Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]

Flammable liquids (Category 2)

Carcinogenicity (Category 1A)

Germ cell mutagenicity (Category 1B)

Specific target organ toxicity - repeated exposure (Category 1)

Aspiration hazard (Category 1)

Eye irritation (Category 2)

Skin irritation (Category 2)

Classification according to EU Directives 67/548/EEC or 1999/45/EC

Highly flammable. May cause cancer. May cause heritable genetic damage. Toxic: danger of serious

damage to health by prolonged exposure through inhalation, in contact with skin and if swallowed. Harmful:

may cause lung damage if swallowed. Irritating to eyes and skin.

Label elements

Labelling according Regulation (EC) No 1272/2008 [CLP]

Pictogram

Signal word

Hazard statement(s)

H225

H304

H315

H319

Danger

Highly flammable liquid and vapour.

May be fatal if swallowed and enters airways.

Causes skin irritation.

Causes serious eye irritation.

H340

H350

H372

Precautionary statement(s)

P201

P210

P301 + P310

P305 + P351 + P338

P308 + P313

P331

Supplemental Hazard

May cause genetic defects.

May cause cancer.

Causes damage to organs through prolonged or repeated exposure.

Obtain special instructions before use.

Keep away from heat/sparks/open flames/hot surfaces. - No smoking.

IF SWALLOWED: Immediately call a POISON CENTER or doctor/

physician.

IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing.

IF exposed or concerned: Get medical advice/ attention.

Do NOT induce vomiting.

none

Statements

Restricted to professional users.

According to European Directive 67/548/EEC as amended.

Hazard symbol(s)

R-phrase(s)

R45

R46

R48/23/24/25

R65

R11

R36/38

S-phrase(s)

S53

S45

May cause cancer.

May cause heritable genetic damage.

Also toxic: danger of serious damage to health by prolonged exposure

through inhalation, in contact with skin and if swallowed.

Also harmful: may cause lung damage if swallowed.

Highly flammable.

Irritating to eyes and skin.

Avoid exposure - obtain special instructions before use.

In case of accident or if you feel unwell, seek medical advice immediately

(show the label where possible).

Restricted to professional users.

2.3

3.1

Other hazards - none

COMPOSITION/INFORMATION ON INGREDIENTS

Substances

Synonyms

Formula

Molecular Weight

Component

Benzene-D6

Hexadeuterobenzene

C6D6

84,15 g/mol

Concentration

CAS-No.

EC-No.

1076-43-3

214-061-8

4.1

FIRST AID MEASURES

Description of first aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed

Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with

water. Consult a physician.

4.2

4.3

5.1

5.2

5.3

5.4

6.1

6.2

6.3

6.4

7.1

Most important symptoms and effects, both acute and delayed

Nausea, Dizziness, Headache, narcosis, Inhalation of high concentrations of benzene may have an initial

stimulatory effect on the central nervous system characterized by exhilaration, nervous excitation and/or

giddiness, depression, drowsiness, or fatigue. The victim may experience tightness in the chest,

breathlessness, and loss of consciousness. Tremors, convulsions, and death due to respiratory paralysis

or circulatory collapse can occur in a few minutes to several hours following severe exposures. Aspiration

of small amounts of liquid immediately causes pulmonary edema and hemorrhage of pulmonary tissue.

Direct skin contact may cause erythema. Repeated or prolonged skin contact may result in drying, scaling

dermatitis, or development of secondary skin infections. The chief target organ is the hematopoietic

system. Bleeding from the nose, gums, or mucous membranes and the development of purpuric spots,

pancytopenia, leukopenia, thrombocytopenia, aplastic anemia, and leukemia may occur as the condition

progresses. The bone marrow may appear normal, aplastic or hyperplastic, and may not correlate with

peripheral blood-forming tissues. The onset of effects of prolonged benzene exposure may be delayed for

many months or years after the actual exposure has ceased., Blood disorders

Indication of any immediate medical attention and special treatment needed

no data available

FIREFIGHTING MEASURES

Extinguishing media

Suitable extinguishing media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Special hazards arising from the substance or mixture

Carbon oxides

Advice for firefighters

Wear self contained breathing apparatus for fire fighting if necessary.

Further information

Use water spray to cool unopened containers.

ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation.

Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to

form explosive concentrations. Vapours can accumulate in low areas.

Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

Methods and materials for containment and cleaning up

Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and

place in container for disposal according to local regulations (see section 13).

Reference to other sections

For disposal see section 13.

HANDLING AND STORAGE

Precautions for safe handling

Avoid exposure - obtain special instructions before use.Avoid contact with skin and eyes. Avoid inhalation

of vapour or mist.

Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic

charge.

7.2

7.3

8.1

8.2

Conditions for safe storage, including any incompatibilities

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are

opened must be carefully resealed and kept upright to prevent leakage.

Handle and store under inert gas. hygroscopic

Specific end uses

no data available

EXPOSURE CONTROLS/PERSONAL PROTECTION

Control parameters

Components with workplace control parameters

Exposure controls

Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and

at the end of workday.

Personal protective equipment

Eye/face protection

Face shield and safety glasses Use equipment for eye protection tested and approved under

appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique

(without touching glove's outer surface) to avoid skin contact with this product. Dispose of

contaminated gloves after use in accordance with applicable laws and good laboratory practices.

Wash and dry hands.

The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and

the standard EN 374 derived from it.

Immersion protection

Material: Fluorinated rubber

Minimum layer thickness: 0,7 mm

Break through time: > 480 min

Material tested:Vitoject? (Anonymous Z677698, Size M)

Splash protection

Material: Fluorinated rubber

Minimum layer thickness: 0,7 mm

Break through time: > 30 min

Material tested:Vitoject? (Anonymous Z677698, Size M)

data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 873000, e-mail sales@kcl.de,

test method: EN374

If used in solution, or mixed with other substances, and under conditions which differ from EN 374,

contact the supplier of the CE approved gloves. This recommendation is advisory only and must

be evaluated by an Industrial Hygienist familiar with the specific situation of anticipated use by our

customers. It should not be construed as offering an approval for any specific use scenario.

Body Protection

Complete suit protecting against chemicals, Flame retardant antistatic protective clothing, The type

of protective equipment must be selected according to the concentration and amount of the

dangerous substance at the specific workplace.

Respiratory protection

Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator

with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup

to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air

respirator. Use respirators and components tested and approved under appropriate government

standards such as NIOSH (US) or CEN (EU).

9.1

PHYSICAL AND CHEMICAL PROPERTIES

Information on basic physical and chemical properties

Appearance

Odour

Odour Threshold

Melting point/freezing

point

Initial boiling point and

boiling range

Flash point

Evaporation rate

Form: liquid

Colour: colourless

no data available

Melting point/range: 6,8 °C

79,1 °C at 1.013 hPa

-11 °C - closed cup

no data available

Flammability (solid, gas) no data available

Upper/lower

flammability or

explosive limits

Vapour pressure

Vapour density

Upper explosion limit: 8 %(V)

Lower explosion limit: 1,3 %(V)

221 hPa at 37,7 °C

99,5 hPa at 20 °C

2,91 - (Air = 1.0)

m) Relative density

0,95 g/cm3 at 20 °C

Water solubility

Partition coefficient: n-

octanol/water

Autoignition

temperature

Decomposition

temperature

Viscosity

Explosive properties

Oxidizing properties

no data available

9.2

10.

10.1

10.2

10.3

10.4

10.5

Other safety information

no data available

STABILITY AND REACTIVITY

Reactivity

no data available

Chemical stability

no data available

Possibility of hazardous reactions

no data available

Conditions to avoid

Heat, flames and sparks. Extremes of temperature and direct sunlight.

Incompatible materials

Acids, Bases, Halogens, Strong oxidizing agents, metal salts

10.6

11.

11.1

Hazardous decomposition products

Other decomposition products - no data available

TOXICOLOGICAL INFORMATION

Information on toxicological effects

Acute toxicity

no data available

Skin corrosion/irritation

no data available

Serious eye damage/eye irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

Laboratory experiments have shown mutagenic effects.

In vivo tests showed mutagenic effects

Carcinogenicity

This is or contains a component that has been reported to be carcinogenic based on its IARC, OSHA,

ACGIH, NTP, or EPA classification.

Human carcinogen.

IARC:

1 - Group 1: Carcinogenic to humans (Benzene-D6)

Reproductive toxicity

no data available

Specific target organ toxicity - single exposure

no data available

Specific target organ toxicity - repeated exposure

no data available

Aspiration hazard

May be fatal if swallowed and enters airways.

Potential health effects

Inhalation

Ingestion

Skin

Eyes

May be harmful if inhaled. Causes respiratory tract irritation.

May be harmful if swallowed. Aspiration hazard if swallowed - can enter

lungs and cause damage.

May be harmful if absorbed through skin. Causes skin irritation.

Causes serious eye irritation.

Signs and Symptoms of Exposure