Benzene,(2-isothiocyanatoethyl)-

1. 1.1 IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING Product identifiers Product name Product Number Brand CAS-No. : : : : Phenethyl isothiocyanate 253731 Anonymous 2257-09-2 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Manufacture of substances 2. 2.1 2.2 HAZARDS IDENTIFICATION Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP] Acute toxicity, Oral (Category 4) Acute toxicity, Inhalation (Category 4) Acute toxicity, Dermal (Category 4) Skin irritation (Category 2) Eye irritation (Category 2) Respiratory sensitization (Category 1) Skin sensitization (Category 1) Specific target organ toxicity - single exposure (Category 3) Classification according to EU Directives 67/548/EEC or 1999/45/EC Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin. May cause sensitization by inhalation. Label elements Labelling according Regulation (EC) No 1272/2008 [CLP] Pictogram Signal word Hazard statement(s) H302 H312 H315 H317 Danger Harmful if swallowed. Harmful in contact with skin. Causes skin irritation. May cause an allergic skin reaction. H319 H332 H334 H335 Precautionary statement(s) P261 P280 P305 + P351 + P338 P342 + P311 Supplemental Hazard Causes serious eye irritation. Harmful if inhaled. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause respiratory irritation. Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. Wear protective gloves/ protective clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/ physician. none Statements According to European Directive 67/548/EEC as amended. Hazard symbol(s) R-phrase(s) R20/21/22 R36/37/38 R42 S-phrase(s) S23 S26 S36 Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin. May cause sensitization by inhalation. Do not breathe vapour. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. 2.3 3. 3.1 Other hazards Lachrymator. COMPOSITION/INFORMATION ON INGREDIENTS Substances Synonyms Formula Molecular Weight Component Phenethyl isothiocyanate : : : 2-Phenylethyl isothiocyanate C9H9NS 163,24 g/mol Concentration CAS-No. EC-No. 2257-09-2 218-855-5 - 4. 4.1 FIRST AID MEASURES Description of first aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. 4.2 4.3 5. 5.1 5.2 5.3 5.4 6. 6.1 6.2 6.3 6.4 7. 7.1 7.2 7.3 8. 8.1 8.2 Most important symptoms and effects, both acute and delayed Cough, Shortness of breath, Headache, Nausea, Vomiting, Repeated exposure may cause asthma., prolonged or repeated exposure can cause:, Lung irritation Indication of any immediate medical attention and special treatment needed no data available FIREFIGHTING MEASURES Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special hazards arising from the substance or mixture Carbon oxides, nitrogen oxides (NOx), Sulphur oxides Advice for firefighters Wear self contained breathing apparatus for fire fighting if necessary. Further information no data available ACCIDENTAL RELEASE MEASURES Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Environmental precautions Do not let product enter drains. Methods and materials for containment and cleaning up Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal. Reference to other sections For disposal see section 13. HANDLING AND STORAGE Precautions for safe handling Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Normal measures for preventive fire protection. Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Recommended storage temperature: 2 - 8 °C Moisture sensitive. Specific end uses no data available EXPOSURE CONTROLS/PERSONAL PROTECTION Control parameters Components with workplace control parameters Exposure controls Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Personal protective equipment Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). 9. 9.1 PHYSICAL AND CHEMICAL PROPERTIES Information on basic physical and chemical properties a) b) c) d) e) f) g) h) Appearance Odour Odour Threshold pH Melting point/freezing point Initial boiling point and boiling range Flash point Evaporation rate Form: clear, liquid Colour: colourless no data available no data available no data available no data available 139 - 140 °C at 15 hPa - lit. 113 °C - closed cup no data available i) Flammability (solid, gas) no data available j) k) l) Upper/lower flammability or explosive limits Vapour pressure Vapour density no data available no data available no data available m) Relative density 1,094 g/cm3 at 25 °C n) o) p) q) r) Water solubility Partition coefficient: n- octanol/water Autoignition temperature Decomposition temperature Viscosity no data available no data available no data available no data available no data available s) t) Explosive properties Oxidizing properties no data available no data available 9.2 10. 10.1 10.2 10.3 10.4 10.5 10.6 11. 11.1 Other safety information no data available STABILITY AND REACTIVITY Reactivity no data available Chemical stability no data available Possibility of hazardous reactions no data available Conditions to avoid Heat. Avoid moisture. Incompatible materials Water, Alcohols, Strong bases, Amines, acids, Strong oxidizing agents Hazardous decomposition products Other decomposition products - no data available TOXICOLOGICAL INFORMATION Information on toxicological effects Acute toxicity LD50 Oral - mouse - 700 mg/kg Skin corrosion/irritation no data available Serious eye damage/eye irritation no data available Respiratory or skin sensitization no data available May cause allergic respiratory and skin reactions Germ cell mutagenicity Genotoxicity in vitro - Hamster - ovary Cytogenetic analysis Genotoxicity in vitro - Hamster - ovary Sister chromatid exchange Genotoxicity in vivo - Mammal - Skin Cytogenetic analysis Genotoxicity in vivo - Mammal - Skin Other mutation test systems Carcinogenicity IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity no data available Specific target organ toxicity - single exposure Inhalation - May cause respiratory irritation. Specific target organ toxicity - repeated exposure no data available Aspiration hazard no data available Potential health effects Inhalation Ingestion Skin Eyes Harmful if inhaled. Causes respiratory tract irritation. Harmful if swallowed. Harmful if absorbed through skin. Causes skin irritation. Causes serious eye irritation. Signs and Symptoms of Exposure Cough, Shortness of breath, Headache, Nausea, Vomiting, Repeated exposure may cause asthma., prolonged or repeated exposure can cause:, Lung irritation Additional Information RTECS: NX9115000 12. 12.1 ECOLOGICAL INFORMATION Toxicity Toxicity to daphnia and other aquatic invertebrates LC50 - Daphnia magna (Water flea) - 0,13 mg/l - 48 h 12.2 12.3 12.4 12.5 12.6 13. 13.1 14. 14.1 Persistence and degradability no data available Bioaccumulative potential no data available Mobility in soil no data available Results of PBT and vPvB assessment no data available Other adverse effects no data available DISPOSAL CONSIDERATIONS Waste treatment methods Product Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Contaminated packaging Dispose of as unused product. TRANSPORT INFORMATION UN number 14.2 ADR/RID: 2206 UN proper shipping name IMDG: 2206 IATA: 2206 ADR/RID: IMDG: IATA: ISOCYANATE SOLUTION, TOXIC, N.O.S. (Phenethyl isothiocyanate) ISOCYANATE SOLUTION, TOXIC, N.O.S. (Phenethyl isothiocyanate) Isocyanate solution, toxic, n.o.s. (Phenethyl isothiocyanate) 14.3 Transport hazard class(es) ADR/RID: 6.1 14.4 Packaging group ADR/RID: III 14.5 Environmental hazards ADR/RID: no IMDG: 6.1 IMDG: III IMDG Marine pollutant: no IATA: 6.1 IATA: III IATA: no 14.6 15. 15.1 15.2 16. Special precautions for user no data available REGULATORY INFORMATION This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006. Safety, health and environmental regulations/legislation specific for the substance or mixture no data available Chemical Safety Assessment no data available OTHER INFORMATION Further information The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information this document is based on the resent state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Lookchem shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale.

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