105826-92-4 Tropisetron Hcl C17H21ClN2O2
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Tropisetron Hydrochloride is a 5-HT3 receptor antagonist used primarily to prevent and treat nausea and vomiting induced by chemotherapy, radiotherapy, or postoperative recovery.
Mechanism: Blocks serotonin (5-HT3) receptors in the gut and central nervous system, inhibiting the vomiting reflex.
Uses:
Chemotherapy-induced nausea/vomiting (CINV).
Postoperative nausea/vomiting (PONV).
Administration: Available as oral tablets, injections, or IV infusions.
Dosage:
Adults: Typically 5 mg once daily (oral or IV), adjusted based on clinical need.
Pediatric use: Limited; dose determined by weight and condition.
Common: Headache, constipation, dizziness.
Rare: QT interval prolongation (cardiac risk), allergic reactions.
Long half-life (~8 hours), allowing once-daily dosing.
Effective for both acute and delayed nausea/vomiting.
Avoid in patients with heart rhythm disorders (due to QT prolongation risk).
Use cautiously with other serotonergic drugs (risk of serotonin syndrome).
Similar to ondansetron and granisetron but with a longer duration of action.
Note: Prescription-only; adherence to dosing guidelines is critical to minimize adverse effects.
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