Melanotan I
Molecular Formula : C78H111N21O19
Molecular Weight : 1646.88
CAS No. : 75921-69-6
Sequence: Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
Researchers there knew that one of the best defenses against skin cancer was a natural tan which has been slowly developed over weeks. They hypothesized that an effective way to reduce skin cancer rates in people would be to induce the body‘s natural tanning system to produce a protective tan prito UV exposure. They knew the body‘s naturally occurring hormone alpha-melanocyte stimulating hormone caused melanogenesis, a process by which the skin‘s tanning cells (melanocytes) produce the skin‘s tanning pigment (melanin). With that knowledge they tested to see if administering this hormone to the body directly could be an effective method to cause sunless tanning. What they found was that while it appeared to work, natural alpha-MSH had too short a half life in the body to be practical as a therapeutic drug. So they decided to find a more potent stable alternative, one that would be more practical.
After synthesizing screening hundreds of molecules, the researchers headed by Dr. VictHruby, found a peptide that after trials testing seemed to not only be safe but also approximately 1,000 times more potent than natural -MSH. They dubbed this new peptide Melanotan. Since their discovery, numerous studies dating back to the mid-1980s have shown no obvious toxic effects of Melanotan. Because skin cancer (melanoma) today is a majhealth concern, Melanotan is expected to be used as a drug to combat it. Melanotan will do this by stimulating the body‘s natural tanning mechanism to create a tan without first needing exposure to harmful levels of UV radiation. This in turn will reduce the potential fskin damage that can eventually lead to skin cancer.
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