Melanotan II(MT-2)
Molecular Formula : C50H69N15O9
Molecular Weight : 1024.2
CAS No. : 121062-08-6
Sequence: Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-NH2(cyclic 2-7)
Developed at the University of Arizona.
A pilot Phase I clinical trial conducted on three males using MT-2 by the College of Medicine, Pharmacology Department, University of Arizona in Tucson, Arizona published in 1996 reported that, MT-2 has tanning activity in humans given only 5 low doses every other day by subcutaneous injection. ((Mild side effects reported included slight nausea increased spontaneous penile erections.
The Department of Pharmacology, University of Arizona College of Medicine published a study in 1998 that involved ten men who suffered from psychogenic erectile dysfunction. Their trial concluded that, Melanotan-II is a potent initiatof erections in men with psychogenic erectile dysfunction has manageable side effects at a dose of 0.025 mg./kg.
A clinical study published in 2000 of 20 men with psychogenicganic erectile dysfunction conducted at the Section of Urology of The University of Arizona College of Medicine concluded, that Melanotan II is a potent initiatof penile erection in men with erectile dysfunction.
After synthesizing screening hundreds of molecules, the researchers headed by Dr. VictHruby, found a peptide that after trials testing seemed to not only be safe but also approximately 1,000 times more potent than natural -MSH. They dubbed this new peptide Melanotan-II (MT-2). Since their discovery, numerous studies dating back to the-1980s have shown no obvious toxic effects of Melanotan-2. Because skin cancer (melanoma) today is a majhealth concern, Melanotan II (MT-2) is expected to be used as a drug to combat it. MT-2 will do this by stimulating the body‘s natural tanning mechanism to create a tan without first needing exposure to harmful levels of UV radiation. This in turn will reduce the potential fskin damage that can eventually lead to skin cancer.
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