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3-Amino-4-phenylbutyric acid hydrochloride 3060-41-1 Phenibut
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γ-Aminobutyric acid (GABA) is an amino acid produced endogenously and is utilized in the adult brain as the primary inhibitory neurotransmitter. In the brain GABA is produced mostly by GABAergic neurons, also known as inhibitory neurons secondary to their primary role surrounding production of their inhibitory neurotransmitter. GABA is very important to normal physiologic function and the absence of a function system revolving around GABA can have drastic effects to health. Spastic diplegia, also known as Little’s Disease, is a condition noted by hypertonicity and spasticity of muscles secondary to the absence of functional GABA receptors in the brain, indicating that, in the absense of GABA, neuroexcitation goes unmitigated.
The body produces GABA through glutamate (the primary excitatory neurotransmitter) metabolism by the enzyme L-glutamic acid decarboxylase in the presence of a vitamin b6 cofactor. Commercially, this same process is replicated using Lactobacillus hilgardii K-3, a bacteria that is found commonly in wine, cider, cheese and cured meats
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