High purity sex powder Tadalafil CAS:171596-29-5 with best price
Min.Order / FOB Price:Get Latest Price
| 1 Kilogram |
FOB Price:USD 80.0000 -100.0000 |
- Min.Order :1 Kilogram
- Purity: 99%
- Payment Terms : L/C,D/A,D/P,T/T,Other
Keywords
High purity Tadalafil cas171596-29-5 high quality Tadalafil
Quick Details
- Appearance:white powder
- Application: used in the treatment of penile erectile dysfunction (ED).
- PackAge:25kg carton drum(32cm*58cm)or 1kg foil bag(10cm*15cm) or by request of clients
- ProductionCapacity:5000|Kilogram|Month
- Storage:
- Transportation:By sea or By air
Superiority:
Superiority
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Details:
Specifications
Sex Function Enhancement Product Tadalafil
1.White powder
2.Assay: 99.8%
3.Fast delivery
4.USP
Certificate Of Analysis
| Name | Tadalafile |
| Appearence | White crystalline powder |
| Cas |
171596-29-5 |
| Assay | ≥99.5% |
| Solubility | Insoluble in water or alcohol, soluble in Acetic acid, ethyl ester |
| Melting point |
300-303°C |
|
Loss on drying |
≤0.5% |
|
Heavy Metal |
≤50ppm |
|
Specific rotation |
[a]20D=+70-72o(C=1.00,CHCl3) |
|
Dosage |
15- 25mg |
| Onset time |
30 minites |
| Grade |
Pharmaceutical Grade |
| Package | 1 kg in an aluminum foil bag, 25kg/drum. |
Function :
In November 2002 the eu approved, in February 2003 for the first time in the UK, Sweden, Denmark, Germany and Australia and other countries successfully listed. On November 21, 2003, approved by FDA he reached that the tablet for the treatment of erectile dysfunction. In May 2005 have been approved by our country, commodity name: when love force (Cialis ®). This product selectivity, less adverse reaction, effect lasts longer than the sildenafil, vardenafil, pharmacokinetic parameters and less affected by alcohol and food.
1 pharmacological effects
1.1 mechanism he reached that not belongs to selective phosphodiesterase (PDE) 5 inhibitors, mechanism mainly involves L - arginine - NO - guanylate cyclase acid - cGMP pathway. In primates (including humans), L - arginine - NO - guanylate cyclase acid - cGMP pathway is the main mechanism of penile erection. CGMP in the corpus cavernosum smooth muscle cells mainly through PDE5 hydrolysis to control the tension of blood vessels. Under normal physiological conditions, O2 and L - arginine in NO synthetase synthesis under the action of endogenous NO; Through sexual stimulation, NO to move through the nervous system to be released into the smooth muscle cells and endothelial cells, and soluble guanylate cyclase acid, changing its configuration, activate the catalytic sites, so as to improve the level of intracellular cGMP; CGMP cGMP dependent protein kinase (PKG), PKG again other protein phosphorylation, the interaction of these proteins and finally results in the decrease of the level of intracellular Ca2 +, arteries and strip smooth muscle relaxation, hyperaemia of artery, vein contraction and penile erection. CGMP mainly were finally PDE5 hydrolysis. Inhibit PDE5, can improve the level of cGMP, leading to arterial blood flow increase, venous congestion, finally can restore the function of the patients with ED.
1.2 pharmacokinetic single oral dose, maximum blood drug concentration after 2 h, significantly slower than sildenafil vardenafil (1 h) and (0.7 ~ 0.9 h). But some clinical studies have shown that oral 16 min after this product can quickly work. Compared with other two kinds of drugs, this product is the most important pharmacokinetic characteristics of long half-life, 17.5 h, significantly longer than sildenafil (4 h) and vardenafil (4 ~ 5 h), although this work slowly, but the efficacy of long duration.
Pharmacokinetic parameters of this product is less affected by age and diabetes factors, basic is not influenced by diet and alcohol intake, these features greatly superior to sildenafil.
This product in the organization distribution of apparent volume of 62.6 L, plasma protein combined rate of 94%, plasma clearance of 2.48 l. h - 1. In the body mainly through the liver metabolism of cytochrome P 503 4 a4, exist in the metabolic product a has a weak activity of catechol glucuronic acid glycosides, for PDE5 inhibition activity was only about 1/13000 of the matrix, but in the normal drug doses, not enough to affect him up to the the efficacy.
1.3 pharmacodynamics of PDE5 has good selectivity, mainly for the MED, the IC50 0.9 nmol L - 1. For PDE6 inhibitory activity was only about 1/780 of the former, IC50 of 730 nmol L, so the retina injury caused by inhibiting PDE6 less adverse reaction. Inhibitory activity of PDE1 ~ 4, 7 ~ 10 up to only 1/9000 of the PDE5 inhibition activity, its corresponding greatly reduce the incidence of adverse reactions. But, now find the product selectivity are still has some shortcomings, for PDE11 selectivity is not high, inhibitory activity for PDE5 1/5, a new study suggests that PDE11 for zhao pill development and sperm production has a certain negative impact. Eosinophils in PDE11 found that its associated with prolactin and the regulation of growth hormone. Inhibition of PDE11 and causes of adverse reactions has not yet been elucidated.
2 drug interactions
[ inhibit PDE5, in turn, affect the cGMP degradation, so the cooperative use of nitrates and can lead to blood pressure fell dramatically, increasing the risk of fainting. CYP3A4 inducers can reduce him up to the the bioavailability, and rifampicin, cimetidine, erythromycin, clarithromycin, itraconazole, ketone health zun, HIV protease inhibitors may enhance the blood drug concentration, should pay attention to adjust the dosage. So far did not see the product of human pharmacokinetic parameters influenced by diet and alcohol.
3 clinical application
Brock on 1 112 cases of normal blood pressure or hypertension and patients with erectile dysfunction, using randomized, double-blind, placebo-controlled clinical Ⅲ period test, dose was 2.5 ~ 20 mg. The results showed that the drug groups compared with placebo group markedly improved erectile function, improve erectile function 81%, 75%, sexual impulse not seen blood pressure conditions affect efficacy. Adverse reactions mainly headache and indigestion, but is generally mild, in the drug group and the placebo group there was no significant difference.
This product in patients with severe ED and related complications has good curative effect. 216 cases of male diabetic ED patients treated with placebo or he reached the, maximum dose of 20 mg, a total of 12 weeks. Does not take into account factors such as age, duration and severity, ED, drug group can obviously increase the sexual function in the placebo group, high dose group in 64
Founded in 2014, as a professional international pharmaceutical corporation,
headquartered in Xi'an (China), KonoChemCo., Ltd. is a leading producer of
standardized herbal extracts, natural active ingredients and APIs for pharmaceutical,
health food and cosmetic industries.
Bulk Herbal Nutrients& Phytochemical Manufacture, Food Ingredients Supplier
The Most Favorable Price Best Quality
Please visit our website: www.konochemical.com
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5. Package of our products
6.Extraction equipment
To know more about our products, please check the catalogue at below:
|
PRODUCTS CATALOGUE OF KONO CHEM |
|||||
|
NO |
NAME |
SOURCE |
PURITY |
STANDARD |
PACKAGE |
|
001 |
Coenzyme Q10 |
Tobacco |
10%-99% |
USP32 |
Drum & Bag |
|
002 |
L-Glutathione |
Yeast |
99% |
JP |
Drum & Bag |
|
003 |
Ecdysterone |
cyanotis arachnoidea |
50%-98% |
CP2005 |
Drum & Bag |
|
004 |
Capsaicin |
Chili pepper |
10%-95% |
USP32 |
Drum & Bag |
|
005 006 |
Matrine Oxymatrine |
Sophora flavescens Sophora flavescens |
1%-98% 1%-98% |
USP32 USP32 |
Drum & Bag Drum & Bag |
|
007 |
Raspberry Ketone |
Raspberry |
99% |
USP32 |
Drum & Bag |
|
008 |
Oleanolic Acid |
ligustrum lucidum ait. |
98% |
CP2010 |
Drum & Bag |
|
009 |
Ursolic Acid |
Eriobotrya japonica(Thunb.)Lindl |
1%-98% |
CP2010 |
Drum & Bag |
|
010 |
Chlorogenic Acid |
Eucommia ulmoides Oliv. |
1%-98% |
CP2010 |
Drum & Bag |
|
011 |
Usnic Acid |
Usneaceae |
98% |
CP2010 |
Drum & Bag |
|
012 |
Shikimic Acid |
Illicium verum Hook.f.) |
98% |
USP32 |
Drum & Bag |
|
013 |
Sinomenine Hcl |
Sinomenium actum Rehd.et |
98% |
USP32 |
Drum & Bag |
|
014 |
Berberine Hcl |
Coptis chinensis Franch |
98% |
CP2010 |
Drum & Bag |
|
015 016 |
Silymarin Silybinin |
Milk thistle Milk thistle |
80% 98% |
EP6 EP6 |
Drum & Bag Drum & Bag |
|
017 018 019 020 021 022 023 |
Lutein Zeaxanthin Lycopene Beta carotene Canthaxanthin Fucoxanthin Astaxanthin |
Marigold flower Marigold flower Tomato Carrot Algae Brown algae Haematococcus pluvialis |
2%-98% 5%-20% 1%-10% 1%-98% 1%-10% 1%-10% 1%-10% |
USP32 IN HOUSE USP32 USP32 USP32 IN HOUSE IN HOUSE |
Drum & Bag Drum & Bag Drum & Bag Drum & Bag Drum & Bag Drum & Bag Drum & Bag |
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