IGF-1 DES
The somatomedins, insulin-like growth factors (IGFs), comprise a family of peptides that play important roles in mammalian growth development. IGF-1 DES is ad form of IGF-1, which mediates many of the growth-promoting effects of growth hormone, with the tri-peptide structure Glycine-Proline-Glutamine cleaved from the N-terminus. It has been isolated from detected in numerous in vivo sources, including the human brain, bovine colostrum, porcine uterus. In vitro studies demonstrate that at equal doses DES (1-3) IGF is ten times more potent than IGF-1 at stimulating hypertrophy proliferation in cultured cells. It is likely generated through post-translational modification in the sequence of circulating mature IGF-1 via protease action.
Insulin-like growth factor-1 (IGF-1) is a single-chain polypeptide of 70 amino acids. It is a trophic factthat circulates at high levels in the blood-stream mediates many, if not most, of the effects of growth hormone. Although the main source of IGF-1 in the serum is the liver, many other tissues synthesize it are sensitive to its trophic action. IGF-1 was called somatomedin in the older literature. IGF-1 insulin have similar three-dimensional structures. IGF-1 appears to influence neuronal structure functions throughout the life span. It has been shown to have the ability to preserve nerve cell function promote nerve growth in experimental studies. Because of these properties, recombinant human IGF-1 is in clinical trials f the treatment of amyotrophic lateral sclerosis (ALS). Recently, recombinant human IGF-1 has entered the dietary supplement marketplace, as have recombinant human growth hormone several so-called growth hormone secretagogues releasers. IGF-DES is the most potent form of IGF-1 on the market today.
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