CasNo.474-25-9,59870-68-7 top quality Chenodeoxycholic acid buy 474-25-9,(474-25-9) Suppliers

1 Kilogram	FOB Price:USD 800.0000 -1000.0000

Min.Order :1 Kilogram
Purity: 98%
Payment Terms : D/A,D/P,T/T,

Keywords

Chenodeoxycholic acid 59870-68-7 top quality buy 474-25-9

Quick Details

Appearance: White or yellowish crystallizstion powder,taste bitter ,with unusual stink
Application: for cholesterol gallstone disease, for courage primality stones and mixed stones have a certain effect
PackAge:25kg/carton drum(32cm*58cm)or 1kg/foil bag(10cm*15cm) or by request of clients
ProductionCapacity:5000|Kilogram|Month
Storage:Store in a cool, dry and and well-sealed container; Keep away from moisture and strong light/heat
Transportation:By sea or By air

Superiority:

Chenodeoxycholic acid is a bile acid that induces apoptosis through protein kinase C signaling pathways.Chenodeoxycholic acid is widely utilized in therapeutic applications. It is applied in medical therapy to dissolve gallstones. It is employed in the treatment of cerebrotendineous xanthomatosis. It is used to treat constipation and cerebrotendineous xanthomatosis. It acts as a urea receptor in supramolecular chemistry which can contain anions. It is a staining additive commonly used with ruthenium or organic photo-sensitizers in the preparation of staining solutions for dye solar cells.

Chenodeoxycholic acid is a bile acid synthesized in the liver from cholesterol. henodeoxycholic acid has been used in a study to assess its effects as a long-term replacement therapy for cerebrotendinous xanthomatosis (CTX). It has also been used in a study to investigate its effects on the small-intestinal absorption of bile acids in patients with ileostomies.

Details:

Chenodeoxycholic Acid, Free Acid and its 7β-isomer ursodeoxycholic acid (sc-204935), are potent (nanomolar affinity) selective inhibitors of DD2 (AKR1C2). These compounds were non-competitive inhibitors of AKR1D1 yielding K_i values of 3.2 μM for chenodeoxycholic acid. This chemical is a hydrophobic primary bile acid, which increases intracellular Ca²⁺ in rat hepatocyte couplets. Studies indicate that Chenodeoxycholic Acid induces apoptosis through a PKC dependent pathway. It is known that Chenodeoxycholic Acid is essential in the metabolism of cholesterol via activation of nuclear receptors. This bile acid can also bind to BABP with a stoichiometery of 1:2. Alternate studies indicate that chenodeoxycholic acid can inhibit the expression of IL-6 and cell viability in QBC939 cells.

Catalogue Number	C291900
Chemical Name	Chenodeoxycholic Acid
Synonyms	(3α,5β,7α)-3,7-Dihydroxycholan-24-oic Acid; (+)-Chenodeoxycholic Acid; 17β-(1-Methyl-3-carboxypropyl)etiocholane-3α,7α-diol; Chenodeoxycholic Acid; Chenodiol; CDC; Chendol; Chenocol; Fluibil; Ursodeoxycholic Acid EP Impurity A;
Impurity	Ursodeoxycholic Acid EP Impurity A
CAS Number	474-25-9
Molecular Formula	C??H??O?
Appearance	White to Pale Beige Solid
Melting Point	>112°C (dec.)
Molecular Weight	392.57
Storage	Refrigerator
Solubility	Dioxane (Slightly), DMSO (Slightly), Methanol (Slightly)
Category	Standards; Steroids; Pharmaceutical/API Drug Impurities/Metabolites;
Applications	Chenodeoxycholic Acid (Ursodeoxycholic Acid EP Impurity A) is a major bile acid in many vertebrates, occurring as the N-glycine and/or N-taurine conjugate. With other bile acids, forms mixed micelles with lecithin in bile which solubilize cholesterol and thus facilitates its excretion. Facilitates fat absorption in the small intestine by micellar solubilization of fatty acids and monoglycerides. Anticholelithogenic. Epimeric with Ursodiol.