Synthetic penicillin acylase / Amidase

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0 Metric Ton	Negotiable

0 Metric Ton

Negotiable

Min.Order :0 Metric Ton
Purity: 80%
Payment Terms : L/C,D/A,D/P,T/T

Keywords

Immobilized penicillin amidase Immobilized penicillin acylase Synthetic Penicillin acylase

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Penicillin G Acylase

Rate of Conversion more than 170

Rate of Side-Chain less than 1.02

Function
catalytic activity
hydrolase activity
Process
physiological process
metabolism
cellular metabolism
drug metabolism
antibiotic metabolism
antibiotic biosynthesis

Details:

Synthetic Penicillin acylase introduction

Penicillin acylase(E.C 3.5.1.11) is the enzyme used commercially for the production of semisyntheticβ-lactam antibiotics and their intermediates. The industrial production of β-lactam antibiotics and their intermediates is undergoing a remarkable transformation traditional chemical conversions based on stoichiometry are being replaced by enzyme-catalyzed processes.

A general production chart of penicillin-derived antibiotics(semi-synthetic penicillins, SSPs, e.g., amoxicillin and ampicillin) and cephalosporin-derived antibiotics (semi-synthetic cephalosporins ,SSCs, e.g., cefadroxil and cephalexin) is outlined in scheme.

The high S/H(synthesis/hydrolysis) ratio in synthesis reactions is compared to commercially available immobilized penicillin acylase. Industrial semi-synthetic antibiotics result from the condensation of a modified side –chain (the acyl donor) to a β-latam nucleus. For example amoxicillin , conversion: 6-APA > 99%, 6-APA:HPGMe≤1.02

Cas:9014-06-6

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