ABT-888 Veliparib 912444-00-9
Product Name:ABT-888(Veliparib) |
Synonyms:MX-1,ABT888 |
Cas No.:912444-00-9 |
Molecular Formula:C13H16N4O |
Molecular Weight:244.29 |
Purity:98% |
Apperarnce:white solid |
Product Name:ABT-888(Veliparib) |
Synonyms:MX-1,ABT888 |
Cas No.:912444-00-9 |
Molecular Formula:C13H16N4O |
Molecular Weight:244.29 |
Purity:98% |
Apperarnce:white solid |
Potent inhibitor of PARP-1 and PARP-2 (potency <5nM in vitro). Does not inhibit other NAD-binding enzymes.Has minimal CYP450 inhibition and induction.Shows broad spectrum of chemo- and radiopotentiation. Enantiomeric purity >97% suitable for in vivo studies. Does not show inherent cytotoxicity and shows no single agent activity in tumor models. Has excellent bioavailability and good blood-brain permeation. Increases tumor growth delay resulting from radiation and DNA-damaging agents.
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