ABT-869

Min.Order / FOB Price:Get Latest Price

1 Metric Ton	Negotiable

1 Metric Ton

Negotiable

Min.Order :1 Metric Ton
Purity: >98%
Payment Terms : T/T,

Keywords

ABT-869 Linifanib 796967-16-3

Quick Details

Appearance:white powder
Application:
PackAge:25kg/drum
ProductionCapacity:1|Metric Ton|Day
Storage:Kept in a cool, dry and ventilated place
Transportation:

Superiority:

Product Name:ABT-869(Linifanib)

Synonyms:AL-39324,RG3635,ABT869

Cas No.:796967-16-3

Molecular Formula:C₂₁H₁₈FN₅O

Molecular Weight:375.41

Purity:98%

Apperarnce:white powder

Details:

Product Name:ABT-869(Linifanib)

Synonyms:AL-39324,RG3635,ABT869

Cas No.:796967-16-3

Molecular Formula:C₂₁H₁₈FN₅O

Molecular Weight:375.41

Purity:98%

Apperarnce:white powder

ABT-869 is multi-targeted in that it is a potent inhibitor of all members of the VEGF and PDGF receptor families (e.g., KDR IC50 value of 4 nM), but has much less activity (IC50 values >1 nM) against unrelated receptor tyrosine kinases, soluble tyrosine kinases or serine/threonine kinases. The kinase inhibition profile of ABT-869 is evident in cellular assays of RTK phosphorylation (IC50 values of 2, 4 and 7 nM for PDGFR, KDR and CSF-1R, respectively) and VEGF-stimulated proliferation (0.2 nM IC50 for human endothelial cells).

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