CasNo.852808-04-9,ABT737,(852808-04-9) Suppliers

1 Metric Ton	Negotiable

Min.Order :1 Metric Ton
Purity: >98%
Payment Terms : T/T,

Keywords

ABT737 ABT-737 852808-04-9

Quick Details

Appearance:white powder
Application:
PackAge:25kg/drum
ProductionCapacity:1|Metric Ton|Day
Storage:Kept in a cool, dry and ventilated place
Transportation:

Superiority:

Product Name:ABT737

Synonyms:ABT-737

Cas No.:852808-04-9

Molecular Formula:C₄₂H₄₅ClN₆O₅S₂

Molecular Weight:813.43

Purity:98%

Apperarnce:yellow solid

A selective inhibitor of BCL-2, in small cell lung cancer. ABT-737 induced dramatic regressions in tumors derived from some SCLC cell lines. In vitro, peripheral blood CLL cells are extremely sensitive to ABT-737 (EC50 ~7 nM).

The Bcl-2 antagonist ABT-737 targets Bcl-2/Bcl-xL ,ABT-737 induces Bax conformational change but fails to activate Bak or trigger Bax translocation. Coadministration of roscovitine and ABT-737 untethers Bak from Mcl-1 and Bcl-xL, respectively, triggering Bak activation and Bax translocation

Details: