17AAG

Min.Order / FOB Price:Get Latest Price

1 Metric Ton	Negotiable

1 Metric Ton

Negotiable

Min.Order :1 Metric Ton
Purity: >99%
Payment Terms : T/T,

Keywords

17AAG Tanespimycin 75747-14-7

Quick Details

Appearance:white powder
Application:
PackAge:25kg/drum
ProductionCapacity:1|Metric Ton|Day
Storage:Keep in cool and dry place, away from light
Transportation:

Superiority:

Product Name:17AAG;Tanespimycin

Synonyms:NSC330507;CP 127374

Cas No.:75747-14-7

M.Wt: 585.69

Formula: C31H43N3O8

Solubility: Soluble in DMSO or Methanol.

Clear Purple solution at 10mg/ml

Purity: >99%

Storage: Storage at -20℃ 2 years

Details:

Product Name:17AAG;Tanespimycin

Synonyms:NSC330507;CP 127374

Cas No.:75747-14-7

M.Wt: 585.69

Formula: C31H43N3O8

Solubility: Soluble in DMSO or Methanol.

Clear Purple solution at 10mg/ml

Purity: >99%

Storage: Storage at -20℃ 2 years

17AAG is a less toxic analogue of the geldanamycin which binds to Hsp90 (Heat Shock Protein 90) and alters it function. Hsp90 plays a key role in regulating the physiology of cells exposed to environmental stress and in maintaining the malignant phenotype of tumor cells. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, and oncogenesis. 17-AAG binds with a high affinity into the ATP binding pocket in Hsp90 and induces the degradation of proteins that require this chaperone for conformational maturation.

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