Barasertib

Min.Order / FOB Price:Get Latest Price

1 Metric Ton	Negotiable

1 Metric Ton

Negotiable

Min.Order :1 Metric Ton
Purity: >99%
Payment Terms : T/T,

Keywords

AZD1152 Barasertib 722544-51-6

Quick Details

Appearance:white powder
Application:
PackAge:25kg/drum
ProductionCapacity:1|Metric Ton|Day
Storage:Keep in cool and dry place, away from light
Transportation:

Superiority:

Product Name:AZD1152-HQPA(Barasertib)

Cas No.:722544-51-6

M.Wt: 507.56

Formula: C26H30FN7O3

Solubility: DMSO

Purity: >99%

Storage: -20℃ 2 years

Details:

Product Name:AZD1152-HQPA(Barasertib)

Cas No.:722544-51-6

M.Wt: 507.56

Formula: C26H30FN7O3

Solubility: DMSO

Purity: >99%

Storage: -20℃ 2 years

AZD1152 is a dihydrogen phosphate prodrug of a pyrazoloquinazoline Aurora kinase inhibitor [AZD1152?Chydroxyquinazoline pyrazol anilide (HQPA)] and is converted rapidly to the active AZD1152-HQPA in plasma . AZD1152-HQPA is a highly potent and selective inhibitor of Aurora B (Ki, 0.36 nM) compared with Aurora A (Ki, 1,369 nM) and has a high specificity versus a panel of 50 other kinases. Consistent with inhibition of Aurora B kinase, addition of AZD1152-HQPA to tumor cells in vitro induces chromosome misalignment, prevents cell division, and consequently reduces cell viability and induces apoptosis.

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