Vitamin K1 99% Hot supplier

Details:

 

Company Introduction:

Onchem (China) Co.,Ltd  is a comprehensive manufacturer and an international distribution of chemicals throughout the world. Specialized in APIs, chemical intermediates, herbal extract and pharmaceutical raw materials. 

 

Product Detailed

 

1.Introduction of Vitamin K1

 

Vitamin K is a group of structurally similar, fat-soluble vitamins that are needed for the posttranslational modification of certain proteins required for blood coagulation and in metabolic pathways in bone and other tissue. They are 2-methyl-1,4-naphthoquinone (3-) derivatives. This group of vitamins includes two natural vitamers: vitamin K1 and vitamin K2. The three basic forms of Vitamin K are K1, K2, and K3.

Vitamin K1, also known as phylloquinone or phytomenadione (also called phytonadione), is synthesized by plants, and is found in highest amounts in green leafy vegetables because it is directly involved in photosynthesis.

 

2.Properties of Vitamin K1

 

(1)ACD/LogP: 12.254  (2)# of Rule of 5 Violations: 1 (3)ACD/LogD (pH 5.5): 12.25  (4)ACD/LogD (pH 7.4): 12.25 (5)ACD/BCF (pH 5.5): 1000000.00  (6)ACD/BCF (pH 7.4): 1000000.00 (7)ACD/KOC (pH 5.5): 10000000.00  (8)ACD/KOC (pH 7.4): 10000000.00 (9)#H bond acceptors: 2  (10)#H bond donors: 0 (11)#Freely Rotating Bonds: 14  (12)Polar Surface Area: 34.14 ?2 (13)Index of Refraction: 1.511  (14)Molar Refractivity: 140.098 cm3 (15)Molar Volume: 467.767 cm3  (16)Polarizability: 55.539 10-24cm3 (17)Surface Tension: 35.5690002441406 dyne/cm  (18)Density: 0.964 g/cm3 (19)Flash Point: 200.441 °C  (20)Enthalpy of Vaporization: 82.553 kJ/mol (21)Boiling Point: 546.44 °C at 760 mmHg  (22)Vapour Pressure: 0 mmHg at 25°C
 

 

3.Structure Descriptors of Vitamin K1

 

SMILES:

CC1=C(C(=O)c2ccccc2C1=O)C/C=C(\C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C

Std. InChI:

InChI=1S/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+/t23-,24-/m1/s1

Std. InChIKey:

MBWXNTAXLNYFJB-NKFFZRIASA-N

 

4.Pharmacodynamics of Vitamin K1

 

Phytonadione is a vitamin, indicated in the treatment of coagulation disorders which are due to faulty formation of factors II, VII, IX and X when caused by vitamin K deficiency or interference with vitamin K activity. Phytonadione aqueous colloidal solution of vitamin K1 for parenteral injection, possesses the same type and degree of activity as does naturally-occurring vitamin K, which is necessary for the production via the liver of active prothrombin (factor II), proconvertin (factor VII), plasma thromboplastin component (factor IX), and Stuart factor (factor X).

 

5.Mechanism of action

 

Vitamin K is an essential cofactor for the gamma-carboxylase enzymes which catalyze the posttranslational gamma-carboxylation of glutamic acid residues in inactive hepatic precursors of coagulation factors II (prothrombin), VII, IX and X. Gamma-carboxylation converts these inactive precursors into active coagulation factors which are secreted by hepatocytes into the blood. Supplementing with Phytonadione results in a relief of vitamin K deficiency symptoms which include easy bruisability, epistaxis, gastrointestinal bleeding, menorrhagia and hematuria.

Package: 10G/pack,100g/pack,1kg/pack (aluminium foil bag)

Storage：2 year

Sample: we provide free sample.

Delivery:

3days by EMS,FEDEX,DHL.

 

 

Factory Picture:

 

 

 

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