Levosulpiride

Levosulpiride

Levosulpiride

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1 Metric Ton

Negotiable

  • Min.Order :1 Metric Ton
  • Purity: 99%
  • Payment Terms : T/T,

Keywords

Levosulpiride 23672-07-3

Quick Details

  • Appearance:white powder
  • Application:
  • PackAge:25kg/plastic drum,200Kg/iron drum
  • ProductionCapacity:1|Metric Ton|Day
  • Storage:Keep in cool and dry place, away from light
  • Transportation:

Superiority:

 

  • 【Density】
  • 1.236 g/cm3
  • 【Melting Point】
  • 183-186℃
  • 【Refractive Index】
  • 1.551
  • 【Storage temp】
  • 2-8°C
  • 【Computed Properties】
  • Molecular Weight:341.42582 [g/mol]
    Molecular Formula:C15H23N3O4S
    XLogP3:0.6
    H-Bond Donor:2
    H-Bond Acceptor:6
    Rotatable Bond Count:6
    Tautomer Count:2
    Exact Mass:341.140927
    MonoIsotopic Mass:341.140927
    Topological Polar Surface Area:110
    Heavy Atom Count:23
    Formal Charge:0
    Complexity:505
    Isotope Atom Count:0
    Defined Atom Stereocenter Count:0
    Undefined Atom Stereocenter Count:1
    Defined Bond Stereocenter Count:0
    Undefined Bond Stereocenter Count:0
    Covalently-Bonded Unit Count:1
    Feature 3D Acceptor Count:4
    Feature 3D Donor Count:2
    Feature 3D Cation Count:1
    Feature 3D Ring Count:2
    Effective Rotor Count:8
    Conformer Sampling RMSD:0.8
    CID Conformer Count:237

Details:

 

Levosulpiride1.Antipsychotic drugs to treat neurological schizophrenia, 2.Also used for intractable vomiting and peptic ulcer 3.antiemetic Antipsychotic drugs to treat neurological schizophrenia, is also used for intractable vomiting, peptic ulcer, and traumatic brain injury, dizziness, headache1.Antipsychotic drugs to treat neurological schizophrenia, 2.Also used for intractable vomiting and peptic ulcer3.antiemetic Antipsychotic drugs to treat neurological schizophrenia, is also used for intractable vomiting, peptic ulcer, and traumatic brain injury, dizziness, headache

 

Safety and Handling

  • 【Safety】

  • The safety of?Levosulpiride (CAS NO.23672-07-3) :
    WGK Germany: 3
    RTECS: BZ3400100

  • 【Specification】

  • ?Levosulpiride , its cas register number is 23672-07-3. It also can be called (S)-(-)-Sulpiride ; (S)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide ;? (-)-N-(((S)-1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide ; Benzamide, 5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-, (S)- (9CI) ; o-Anisamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-, (S)-(-)- .It?is an antipsychotic.

Biomedical Effects and Toxicity

  • 【Biological Activity】
  • Active enantiomer. Selective D 2 -like dopamine antagonist (K i values are ~ 0.015. ~ 0.013, 1, ~ 45 and ~ 77 μ M at D 2 , D 3 , D 4 , D 1 and D 5 receptors respectively).
  • 【Pharmacological Action】
  • - A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake.
    - Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.
    - Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.

 

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