Paliperidone

Paliperidone

Paliperidone

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1 Metric Ton

Negotiable

  • Min.Order :1 Metric Ton
  • Purity: 99%
  • Payment Terms : T/T,

Keywords

Paliperidone 144598-75-4

Quick Details

  • Appearance:white powder
  • Application:
  • PackAge:25kg/plastic drum,200Kg/iron drum
  • ProductionCapacity:1|Metric Ton|Day
  • Storage:Keep in cool and dry place, away from light
  • Transportation:

Superiority:

 

  • 【Density】
  • 1.45 g/cm3
  • 【Melting Point】
  • 158-160°C
  • 【Boiling Point】
  • 612.3 °C at 760 mmHg
  • 【Vapour】
  • 0mmHg at 25°C
  • 【Refractive Index】
  • 1.692
  • 【Flash Point】
  • 324.1 °C
  • 【Storage temp】
  • Room temp
  • 【Computed Properties】
  • Molecular Weight:426.483883 [g/mol]
    Molecular Formula:C23H27FN4O3
    XLogP3-AA:2.2
    H-Bond Donor:1
    H-Bond Acceptor:7
    Rotatable Bond Count:4
    Exact Mass:426.206719
    MonoIsotopic Mass:426.206719
    Topological Polar Surface Area:82.2
    Heavy Atom Count:31
    Formal Charge:0
    Complexity:764
    Isotope Atom Count:0
    Defined Atom Stereocenter Count:0
    Undefined Atom Stereocenter Count:1
    Defined Bond Stereocenter Count:0
    Undefined Bond Stereocenter Count:0
    Covalently-Bonded Unit Count:1
    Feature 3D Acceptor Count:3
    Feature 3D Donor Count:1
    Feature 3D Cation Count:1
    Feature 3D Ring Count:5
    Effective Rotor Count:6
    Conformer Sampling RMSD:0.8
    CID Conformer Count:168

Details:

 

Safety and Handling

  • 【Hazard Codes】
  • T: Toxic;
  • 【Risk Statements】
  • R25
  • 【Safety Statements 】
  • 45
  • 【Safety】

  • Safety Information of Paliperidone (CAS NO.144598-75-4):
    Hazard Codes: TToxic
    Risk Statements: 25
    R25 :Toxic if swallowed.???
    Safety Statements: 45
    S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
    RIDADR: UN 2811 6.1/PG 3
    RTECS: UV1164720

  • 【Transport】
  • UN 2811 6.1/PG 3
  • 【Specification】

  • ?Paliperidone , its CAS NO. is 144598-75-4, the synonyms are (9RS)-3-(2-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-
    yl))ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido(1,2-a)pyrimidin-4-one ; 4H-Pyrido(1,2-a)pyrimidin-4-one, 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl- ; 9-Hydroxyrisperidone ; Invega ; Paliperidone ; RO76477 ; UNII-838F01T721 .

Use and Manufacturing

  • 【Usage】

  • It is indicated for the acute and maintenance treatment of schizophrenia. The drug significantly reduces side-effects present in other anti-psychotic drugs formerly used to treat schizophrenia and bipolar disorder. In short-term studies paliperidone has been shown to be effective, demonstrating improvements in symptom scores, compared with placebo.

Biomedical Effects and Toxicity

  • 【Pharmacological Action】
  • - Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.

 

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