Baclofen

Details:

• Safety and Handling

  • 【Hazard Codes】
  • T:Toxic;
  • 【Risk Statements】
  • R61;R25;R36/37/38;R42/43
  • 【Safety Statements 】
  • S52;S22;S36/37/39;S45
  • 【HazardClass】
  • 6.1(b)
  • 【Safety】

  • Poison by ingestion, subcutaneous and intravenous routes. Human systemic effects by ingestion: blood pressure lowering, coma, muscle weakness, pulse rate decrease, respiratory depression. When heated to decomposition it emits toxic fumes of Cl⁻ and NO_x. A muscle relaxant.
    Safety Information of Baclofen (CAS NO.1134-47-0)
    Hazard Codes:  T,Xn
    Risk Statements: 61-25-36/37/38-42/43-20/21/22 
    R61:May cause harm to the unborn child. 
    R25 :Toxic if swallowed. 
    R36/37/38:Irritating to eyes, respiratory system and skin. 
    R42/43:May cause sensitization by inhalation and skin contact. 
    R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
    Safety Statements: 53-22-36/37/39-45-52-26 
    S53:Avoid exposure - obtain special instructions before use. 
    S22:Do not breathe dust. 
    S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
    S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
    S52:Not recommended for interior use on large surface areas. 
    S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
    RIDADR: UN 2811 6.1/PG 3
    WGK Germany: 3
    RTECS: MW5084200
    HazardClass: 6.1(b)
    PackingGroup: III

  • 【PackingGroup 】
  • III
  • 【Transport】
  • UN 2811

  Use and Manufacturing

  • 【Usage】
  • Specific GABA-B receptor agonist. Muscle relaxant (skeletal)

  Biomedical Effects and Toxicity

  • 【Biological Activity】
  • Selective GABA B receptor agonist. Skeletal muscle relaxant.
  • 【Pharmacological Action】
  • - Endogenous compounds and drugs that bind to and activate GABA-B RECEPTORS.
    - A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358)