Tacrolimus monohydrate price Tacrolimus monohydrate CAS 109581-93-3 Tacrolimus monohydrate supplier in China
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TACROLIMUS Chemical Properties |
storage temp. | −20°C |
Safety Information |
Hazard Codes | T |
Risk Statements | 25 |
Safety Statements | 45 |
RIDADR | UN 2811 6.1/PG 3 |
RTECS | KD4201200 |
TACROLIMUS Usage And Synthesis |
Usage | immune suppressant, antifungal |
Biological Activity | Potent calcineurin (protein phosphatase 2B) inhibitor that requires FK 506-binding protein 12 (FKBP12) for activity (IC 50 = 3 nM). Inhibits secretion of IL-1, IL-2 (IC 50 = 1 nM), IL-3, IL-4, IL-6 (IC 50 = 35 nM), GM-CSF, TNF α (IC 50 = 10 nM), IFN γ and Myc from activated T-cells in vitro . Exhibits potent immunosuppressive, neuroprotective and anticonvulsant activity in vivo |
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