CasNo.59865-13-3,Cyclosporin A,(59865-13-3) Suppliers

1 Kilogram	Negotiable

Min.Order :1 Kilogram
Purity: 99%
Payment Terms : L/C,T/T,Other

Keywords

Cyclosporin A price Cyclosporin A CAS 59865-13-3 Cyclosporin A supplier in China

Quick Details

Appearance:white powder
Application:Cyclosporin A is a hydrophobic cyclic peptide isolated from several fungal species including Cylindrocarpon, Fusarium, Trichoderma and Tolypocladium. Cyclosporin A inhibits T-cell activation and has b
PackAge:25kg/bucket or as per your request
ProductionCapacity:1|Metric Ton|Month
Storage:Stored in cool, dry and ventilation place; Away from fire and heat
Transportation:by courier door to door or by sea

Superiority:

Superior quality, moderate price & quick delivery.

Details:

Cyclosporin A Chemical Properties

mp	148-151°C
storage temp.	2-8°C
solubility	ethanol: 30 mg/mL
form	solid
color	white
Merck	13,2781
CAS DataBase Reference	59865-13-3(CAS DataBase Reference)
EPA Substance Registry System	Cyclosporin A(59865-13-3)

Safety Information

Hazard Codes	T,Xn
Risk Statements	45-60-22-40
Safety Statements	53-45-36/37-24/25-22
WGK Germany	3
RTECS	GZ4120000
Hazardous Substances Data	59865-13-3(Hazardous Substances Data)

MSDS Information

Provider	Language
Cyclosporin A	English
SigmaAldrich	English

Cyclosporin A Usage And Synthesis

Chemical Properties	White Powder
Usage	prothrombogenic agent
Usage	Cyclosporin A is a hydrophobic cyclic peptide isolated from several fungal species including Cylindrocarpon, Fusarium, Trichoderma and Tolypocladium. Cyclosporin A inhibits T-cell activation and has been marketed since 1983 as an immunosuppressant in post-allogeneic organ transplant. Cyclosporin A acts by binding to the protein, cyclophilin (immunophilin), in T-lymphocytes causing inhibition of calcineurin (protein phosphatase 2B). Cyclosporin A reduces transcription of interleukin 2, and inhibits lymphokine production, interleukin release and NO synthesis induced by interleukin 1α, lipopolysaccharides and TNFα.
Usage	An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
General Description	White prismatic needles (from acetone) or white powder.
Air & Water Reactions	Slightly water soluble .
Reactivity Profile	Cyclosporin A is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Health Hazard	SYMPTOMS: Symptoms of exposure to Cyclosporin A include hepatotoxicity, nephrotoxicity, hyperkalemia, hyperuricemia, convulsions, renal dysfunction, tremor, hirsutism, hypertension, gum hyperplasia, cramps, acne, headache, diarrhea, nausea, vomiting, abdominal discomfort, paresthesia, flushing, leukopenia, lymphoma, sinusitis and gynecomastia. In 2% or less of persons exposed, it has caused allergic reactions, anemia, anorexia, confusion, conjunctivitis, edema, fever, brittle fingernails, gastritis, hearing loss, hiccups, hyperglycemia, muscle pain, peptic ulcer, thrombocytopenia and tinnitus. Rare reactions include anxiety, chest pain, constipation, depression, hair breaking hematuria, joint pain, lethargy, mouth sores, myocardial infarction, night sweats, pancreatitis, pruritus, swallowing difficulty, tingling, upper gastrointestinal bleeding, visual disturbance, weakness and weight loss. It has caused kidney and liver damage. An increased susceptibility to infection may occur. Other symptoms include gastrointestinal disturbance, rashes and angioedema.
Fire Hazard	Flash point data for Cyclosporin A are not available; however, Cyclosporin A is probably combustible.