5-Azacytidine price 5-Azacytidine CAS 320-67-2 5-Azacytidine supplier in China
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5-Azacytidine Chemical Properties |
mp | 226-232 °C (dec.)(lit.) |
alpha | 40 º (C=1, H2O 22 ºC) |
storage temp. | 2-8°C |
form | lyophilized powder |
Water Solubility | 0.5-1.0 g/100 mL at 21 ºC |
Merck | 887 |
CAS DataBase Reference | 320-67-2(CAS DataBase Reference) |
EPA Substance Registry System | 1,3,5-Triazin-2( 1H)-one, 4-amino-1-.beta.-D-ribofuranosyl- (320-67-2) |
Safety Information |
Hazard Codes | T |
Risk Statements | 45-46-22 |
Safety Statements | 53-22-36/37/39-45 |
WGK Germany | 3 |
RTECS | XZ3017500 |
F | 10-23 |
Hazardous Substances Data | 320-67-2(Hazardous Substances Data) |
MSDS Information |
Provider | Language |
---|---|
5-Azacytidine | English |
ACROS | English |
SigmaAldrich | English |
5-Azacytidine Usage And Synthesis |
Chemical Properties | White-to-Off-White Crystalline Solid |
Usage | A potent growth inhibitor and cytotoxic agent. It acts as a demethylating agent by inhibiting DNA methyltransferase |
Usage | Antineoplastic;'Antimetabolite |
Usage | antianginal |
General Description | White crystalline powder. |
Air & Water Reactions | Slightly water soluble. Unstable in solution. |
Reactivity Profile | 5-Azacytidine is sensitive to light (may discolor). 5-Azacytidine is sensitive to oxidation. 5-Azacytidine is unstable in solution. 5-Azacytidine undergoes hydrolysis in aqueous buffers. 5-Azacytidine is incompatible with strong oxidizers. |
Fire Hazard | Flash point data for 5-Azacytidine are not available; however, 5-Azacytidine is probably combustible. |
Biological Activity | DNA methyltransferase inhibitor. Incorporates into DNA forming covalent adducts with cellular DNMT1, depleting enzyme activity. Induces demethylation and reactivation of silenced genes. Improves the efficiency of reprogramming of stem cells. |
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