64228-81-5 Atracurium Atracurium besylate
Name: | Atracurium besylate |
---|---|
CAS No.: | 64228-81-5 |
Molecular Structure: | |
Formula: | C53H72N2O12.2(C6H5O3S) |
Molecular Weight: | 1243.48 |
Synonyms: | Tracrium;Atracurii besilas [INN-Latin];Atracurium Besilate injection;Besilate datracurium [INN-French];Isoquinolinium, 2,2-(1,5-pentanediylbis(oxy(3-oxo-3,1-propanediyl)))bis(1-((3,4-dimethoxyphenyl)methyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, dibenzenesulfonate;Atracurium besilate;Track detectorsTracrium;BW 33A;Tracrium (TN);Besilato de atracurio [INN-Spanish];Atracurium besylate (USP);Atracurii besilas;Atracurium besy; |
EINECS: | 264-743-4 |
Density: | |
Melting Point: | 85-90 °C |
Boiling Point: |
Name: | Atracurium besylate |
---|---|
CAS No.: | 64228-81-5 |
Molecular Structure: | |
Formula: | C53H72N2O12.2(C6H5O3S) |
Molecular Weight: | 1243.48 |
Synonyms: | Tracrium;Atracurii besilas [INN-Latin];Atracurium Besilate injection;Besilate datracurium [INN-French];Isoquinolinium, 2,2-(1,5-pentanediylbis(oxy(3-oxo-3,1-propanediyl)))bis(1-((3,4-dimethoxyphenyl)methyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, dibenzenesulfonate;Atracurium besilate;Track detectorsTracrium;BW 33A;Tracrium (TN);Besilato de atracurio [INN-Spanish];Atracurium besylate (USP);Atracurii besilas;Atracurium besy; |
EINECS: | 264-743-4 |
Density: | |
Melting Point: | 85-90 °C |
Boiling Point: |
Test |
Standard |
Result |
Appearance |
White to yellowish-white powder, slightly hygroscopic, odorless. |
Conforms |
Solubility |
Very soluble in acetonitrile and chloroform, soluble in water and practically insoluble in ether. |
Conforms |
Identification |
(1) IR |
Conforms |
(2) HPLC |
Conforms |
|
Water |
NMT5.0% |
0.4% |
Residue on ignition |
NMT0.2% |
0.2% |
Heavy metals |
NMT20ppm |
<20ppm |
Methyl benzenesulfonate |
NMT0.01% |
0.00004% |
Toluene |
NMT 890ppm ( ICH) |
91ppm |
Chromatographic purity |
(1) Laudanosine: NMT 0.5% |
0.04% |
(2) Any other individual impurity: NMT 1.0% |
0.38% |
|
(3) Total impurities: NMT 3.5% |
0.90% |
|
Isomer ratio |
(1) trans-trans isomer: 5.0% ~ 6.5% |
5.6% |
(2) cis-trans isomer: 34.5% ~ 38.5% |
35.5% |
|
(3) cis-cis isomer: 55.0% ~ 60.0% |
58.9% |
|
Assay |
96.0% ~102.0% (C65H82N2O18S2 on the anhydrous basis) |
98.9% |
Residual solvents |
(1)Dichloromethane: NMT 600ppm |
Undetected |
(2)Acetonitrile: NMT 410ppm |
Undetected |
|
(3)Ethyl ether: NMT 5000ppm |
3474ppm |
|
Result: Conforms to USP 35. |
||
Storage: Preserve in tight, light-resistant containers, in a cold place. |
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