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Letrozole Breast Cancer Treatment Letrozole 112809-51-5
Letrozole is use for the treatment of local or metastatic breast cancer that is hormone receptor positive or has an unknown receptor status in postmenopausal women.Letrozole has been used for ovarian stimulation by fertility doctors since 2001 because it has fewer side-effects than clomiphene (Clomid) and less chance of multiple gestation. A study presented at the American Society of Reproductive Medicine 2005 Conference suggests that letrozole may increase the risk of birth defects.
Description:
Letrozole
Alias: Femara
CAS No: 112809-51-5
MF: C17H11N5
MW: 285.3
Purity: 98%
Appearance: white powder.
Applications:
Femara (letrozole) is a type II (non-steroidal) third generation aromatase inhibitor. Clinically it is used to treat postmenopausal women with either estrogen receptor positive or estrogen receptor unknown breast cancer.
In women with breast cancer, it has been shown to reduce estrogen levels by 98% or more (1). However, it’s use and benefits are not limited to eliminating estrogen in women.
For pre-contest bodybuilders, Letrozole is almost a necessity to eliminate water retention and achieve the ripped look necessary to compete in today’s bodybuilding world. However, in my experience, it is only necessary to be used for the last 4-6 weeks, to eliminate excess estrogen and water retention. After using Letrozole I recommend staying away from any estrogen suppression for at least a month to try to normalize the body.
Specifications:
Tests |
Specifications |
Results |
Appearance |
White or off-white crystaline powder |
White Crystalline powder |
Solubility
|
Soluble in Chloroform; Soluble in ethanol when heated |
Conform |
ldentification |
(1)Maximum absorption in wavelength of 240 nm Minimum absorption in wavelength of 215 nm |
Conform Conform |
(2)Infrared spectrum should be in accordance the dominant peak of contrast |
In accordance with the dominant peak of contrast |
|
Melting points |
182℃-184℃ |
182℃ |
Related substances |
≤0.5% |
0.3% |
Single impurity |
≤0.3% |
0.2% |
Loss on drying |
≤1.0% |
0.8% |
[Assay]C17H11N5 (On anhydrous basis) |
≥98.0% |
99.2% |
Conclusion |
Conforms Specifications of Enterprise Standard. |
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