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High quality picoplatin picoplatin 181630-15-9
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Product Name: Picoplatin(AMD-473); NeoRx;AMD473; NX 473;ZD0473;NX-473, ZD-473, ZD-0473, AMD-473, JM-473 |
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CAS No.:181630-15-9 |
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Chemical Name: Cis-Amminedichloro (2-Methylpyridine) Platinum;Azane 2-methylpyridine platinum(II) dichloride;Amminedichloro(2-methylpyridine)platinium |
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Molecular Formula |
C6H10N2Cl2Pt |
Molecular Weight: |
376.25 |
Batch No.: |
20131203 |
Mfg. Date: |
2013.12.18 |
Quantity: | 10G | Retest Date: | 2016.12.17 |
Structure: |
Items |
Specifications |
Results |
Appearance: |
Pale yellow, crystalline powder; odorless |
Complies |
Identification: |
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(1)UV: Maximum absorption:349nm and 297nm Minimum absorption: 325nm and 271nm |
Complies
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(2)IR: The positions and the relative sizes of the bands in the spectrum of the sample are concordant with those in the spectrum of the reference standard. |
Complies
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Test |
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Appearance of solution: Clear |
Complies |
Acidity: 5.5~7.5 |
5.9 |
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Related substances: If impurity peak appears in HPLC, the sum of the areas of all the peaks apart from the principal peak is not more than the area of the principal peak in the chromatogram obtained with reference solution.(2.0%) |
Complies
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Loss on drying: |
NMT0.5% |
0.2% |
Assay: |
98.0~102.0% |
99.2% |
Storage: Preserve in tightly-closed container, Keep away from light.
Application:Small cell lung cancer, colorectal cancer, prostate cancer; An extended spectrum of antineoplastic activity.
Picoplatin is a new generation organic platinum analog with an extended spectrum of antineoplastic activity. Designed to overcome platinum drug resistance.Picoplatin alkylates DNA, forming both inter- and intra-strand cross-linkages, resulting in inhibition of DNA replication and transcription, and the induction of apoptosis,
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