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1 Kilogram |
Negotiable |
Estradiol hemihydrate Estradiol Estradiol hydrate
EP standard ≥97.5%
Estradiol hemihydrate
Appearance
|
White or almost white, crystalline powder or colourless crystals |
Solubility
|
Practically insoluble in water, soluble in acetone, sparingly soluble in alcohol, slightly soluble in ether and in methylene chloride |
Identification |
A:IR B:TLC C:Positive |
Specific optical rotation |
+76.0°~ +83.0° |
Melting range |
175~180℃ |
Water |
2.9%~3.5% |
Related Substance |
Impurity A ≤ 0.3% |
|
Impurity B ≤ 0.3% |
|
Impurity C ≤ 0.3% |
|
Impurity D ≤ 0.3% |
|
Total impurities ≤ 0.5% |
|
Any other impurity ≤ 0.1% |
Residual Solvents |
Alcohol≤0.5% |
Assay |
97.0~103.0% (on the dried basis) |
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